Research output per year
Research output per year
- 1 - 50 out of 328 results
Search results
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2023
Nitric oxide-loaded nano- and microparticle platforms serving as potential new antifungal therapeutics
Liu, S., Zamith-Miranda, D., Almeida-Paes, R., da Silva, L. B. R., Nacharaju, P. & Nosanchuk, J. D., Jul 1 2023, In: Fungal Biology. 127, 7-8, p. 1224-1230 7 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
2022
Melanization of Candida auris Is Associated with Alteration of Extracellular pH
Smith, D. F. Q., Mudrak, N. J., Zamith-Miranda, D., Honorato, L., Nimrichter, L., Chrissian, C., Smith, B., Gerfen, G., Stark, R. E., Nosanchuk, J. D. & Casadevall, A., Oct 2022, In: Journal of Fungi. 8, 10, 1068.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
2021
A novel therapeutic approach to corneal alkaline burn model by targeting fidgetin-like 2, a microtubule regulator
Wang, J., Dey, A., Kramer, A. H., Miao, Y., Liu, J., Baker, L., Friedman, J. M., Nacharaju, P., Chuck, R. S., Zhang, C. & Sharp, D. J., 2021, In: Translational Vision Science and Technology. 10, 1, p. 1-11 11 p., 17.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Candida glabrata produces a melanin-like pigment that protects against stress conditions encountered during parasitism
Almeida-Paes, R., Figueiredo-Carvalho, M. H. G., Da Silva, L. B. R., Gerfen, G., De S Araújo, G. R., Frases, S., Zancopé-Oliveira, R. M. & Nosanchuk, J. D., May 2021, In: Future Microbiology. 16, 7, p. 509-520 12 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Characterization of the structural determinants of the ubiquitin-dependent proteasomal degradation of human hepatic tryptophan 2,3-dioxygenase
Liu, Y., Kim, S. M., Wang, Y., Karkashon, S., Lewis-Ballester, A., Yeh, S. R. & Correia, M. A., May 2021, In: Biochemical Journal. 478, 10, p. 1999-2017 19 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Conformational Plasticity in Human Heme-Based Dioxygenases
Pham, K. N., Lewis-Ballester, A. & Yeh, S. R., Feb 3 2021, In: Journal of the American Chemical Society. 143, 4, p. 1836-1845 10 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration
Baker, L., Tar, M., Kramer, A. H., Villegas, G. A., Charafeddine, R. A., Vafaeva, O., Nacharaju, P., Friedman, J., Davies, K. P. & Sharp, D. J., May 10 2021, In: JCI Insight. 6, 9, e138484.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2020
Control of systemic inflammation through early nitric oxide supplementation with nitric oxide releasing nanoparticles
Williams, A. T., Muller, C. R., Govender, K., Navati, M. S., Friedman, A. J., Friedman, J. M. & Cabrales, P., Dec 2020, In: Free Radical Biology and Medicine. 161, p. 15-22 8 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Narrow-Spectrum Antibiotic Targeting of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis
Carl, A. G., Harris, L. D., Feng, M., Nordstrøm, L. U., Gerfen, G. J., Evans, G. B., Silakov, A., Almo, S. C. & Grove, T. L., Jul 14 2020, In: Biochemistry. 59, 27, p. 2562-2575 14 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
NO Candida auris: Nitric oxide in nanotherapeutics to combat emerging fungal pathogen Candida auris
Cleare, L. G., Li, K. L., Abuzeid, W. M., Nacharaju, P., Friedman, J. M. & Nosanchuk, J. D., Jun 2020, In: Journal of Fungi. 6, 2, p. 1-13 13 p., 85.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Novel nitric oxide‒generating platform using manuka honey as an anti-biofilm strategy in chronic rhinosinusitis
Yang, C., Mavelli, G. V., Nacharaju, P., Li, K., Cleare, L. G., Nosanchuk, J. D., Friedman, J. M. & Abuzeid, W. M., Feb 1 2020, In: International Forum of Allergy and Rhinology. 10, 2, p. 223-232 10 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Structure-function analyses of the G729R 2-oxoadipate dehydrogenase genetic variant associated with L-lysine metabolism disorder
Zhang, X., Nemeria, N. S., Leandro, J., Houten, S., Lazarus, M., Gerfen, G., Ozohanics, O., Ambrus, A., Nagy, B., Brukh, R. & Jordan, F., Jun 2020, In: Journal of Biological Chemistry. 295, 23, 012761.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2019
Anti-biofilm activity of garlic extract loaded nanoparticles
Girish, V. M., Liang, H., Aguilan, J. T., Nosanchuk, J. D., Friedman, J. M. & Nacharaju, P., Aug 2019, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 20, 102009.Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase
Winters, M., DuHadaway, J. B., Pham, K. N., Lewis-Ballester, A., Badir, S., Wai, J., Sheikh, E., Yeh, S. R., Prendergast, G. C., Muller, A. J. & Malachowski, W. P., Jan 15 2019, In: European Journal of Medicinal Chemistry. 162, p. 455-464 10 p.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
High fat diet aggravates cardiomyopathy in murine chronic Chagas disease
Lizardo, K., Ayyappan, J. P., Cui, M. H., Balasubramanya, R., Jelicks, L. A. & Nagajyothi, J. F., Jan 1 2019, In: Microbes and Infection. 21, 1, p. 63-71 9 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Both Generate Superoxide/H2O2 in a Side Reaction and Each Could Contribute to Oxidative Stress in Mitochondria
Jordan, F., Nemeria, N. & Gerfen, G., Oct 1 2019, In: Neurochemical Research. 44, 10, p. 2325-2335 11 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Reducing Ischemia/Reperfusion Injury by the Targeted Delivery of Nitric Oxide from Magnetic-Field-Induced Localization of S-Nitrosothiol-Coated Paramagnetic Nanoparticles
Navati, M. S., Lucas, A., Liong, C., Barros, M., Jayadeva, J. T., Friedman, J. M. & Cabrales, P., May 27 2019, In: ACS Applied Bio Materials. 2, 7, p. 2907-2919 13 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Semisynthetic supra plasma expanders: a new class of therapeutics to improve microcircualtion in sickle cell anaemia
Meng, F., Kaul, D., Thangaswamy, S., Bhutoria, S., Gerfen, G., Branch, C., Intaglietta, M. & Acharya, S. A., Dec 4 2019, In: Artificial Cells, Nanomedicine and Biotechnology. 47, 1, p. 73-82 10 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Snapshot of an oxygen intermediate in the catalytic reaction of cytochrome c oxidase
Ishigami, I., Lewis-Ballester, A., Echelmeier, A., Brehm, G., Zatsepin, N. A., Grant, T. D., Coe, J. D., Lisova, S., Nelson, G., Zhang, S., Dobson, Z. F., Boutet, S., Sierra, R. G., Batyuk, A., Fromme, P., Fromme, R., Spence, J. C. H., Ros, A., Yeh, S. R. & Rousseau, D. L., Feb 26 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3572-3577 6 p.Research output: Contribution to journal › Article › peer-review
Open Access66 Scopus citations -
Structural Basis of Inhibitor Selectivity in Human Indoleamine 2,3-Dioxygenase 1 and Tryptophan Dioxygenase
Pham, K. N., Lewis-Ballester, A. & Yeh, S. R., Nov 27 2019, In: Journal of the American Chemical Society. 141, 47, p. 18771-18779 9 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster
Bashiri, G., Grove, T. L., Hegde, S. S., Lagautriere, T., Gerfen, G. J., Almo, S. C., Squire, C. J., Blanchard, J. S. & Baker, E. N., Aug 30 2019, In: Journal of Biological Chemistry. 294, 35, p. 13158-13170 13 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2018
Evidence for functional and regulatory cross-talk between the tricarboxylic acid cycle 2-oxoglutarate dehydrogenase complex and 2-oxoadipate dehydrogenase on the L-lysine, L-hydroxylysine and L-tryptophan degradation pathways from studies in vitro
Nemeria, N. S., Gerfen, G., Yang, L., Zhang, X. & Jordan, F., Sep 2018, In: Biochimica et Biophysica Acta - Bioenergetics. 1859, 9, p. 932-939 8 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Inhibition Mechanisms of Human Indoleamine 2,3 Dioxygenase 1
Lewis-Ballester, A., Karkashon, S., Batabyal, D., Poulos, T. L. & Yeh, S. R., Jul 11 2018, In: Journal of the American Chemical Society. 140, 27, p. 8518-8525 8 p.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
L-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum
Almeida-Paes, R., Almeida-Silva, F., Pinto, G. C. M., De Abreu Almeida, M., De Medeiros Muniz, M., Pizzini, C. V., Gerfen, G. J., Nosanchuk, J. D. & Zancopé-Oliveira, R. M., Jun 1 2018, In: Medical mycology. 56, 4, p. 506-509 4 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Mechanism for Fluorescence Quenching of Tryptophan by Oxamate and Pyruvate: Conjugation and Solvation-Induced Photoinduced Electron Transfer
Peng, H. L. & Callender, R., Jun 28 2018, In: Journal of Physical Chemistry B. 122, 25, p. 6483-6490 8 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Oxidative decarboxylation of pyruvate by 1-deoxy-D-xyulose 5-phosphate synthase, a central metabolic enzyme in bacteria
DeColli, A. A., Nemeria, N. S., Majumdar, A., Gerfen, G. J., Jordan, F. & Freel Meyers, C. L., Jul 13 2018, In: Journal of Biological Chemistry. 293, 28, p. 10857-10869 13 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species
Nemeria, N. S., Gerfen, G., Nareddy, P. R., Yang, L., Zhang, X., Szostak, M. & Jordan, F., Feb 1 2018, In: Free Radical Biology and Medicine. 115, p. 136-145 10 p.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
Trypanosoma cruzi produces the specialized proresolving mediators resolvin D1, resolvin D5, and resolvin E2
Colas, R. A., Ashton, A. W., Mukherjee, S., Dalli, J., Akide-Ndunge, O. B., Huang, H., Desruisseaux, M. S., Guan, F., Jelicks, L. A., dos Santos, F. M., Nagajyothi, J., Zingman, M. A., Reyes, J., Weiss, L. M., Serhan, C. N. & Tanowitz, H. B., Apr 1 2018, In: Infection and immunity. 86, 4, e00688-17.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2017
Dantrolene improves in vitro structural changes induced by serum from Trypanosoma cruzi-infected mice
Malvestio, L. M., Celes, M. R. N., Jelicks, L. A., Tanowitz, H. B. & Prado, C. M., Jan 1 2017, In: Parasitology research. 116, 1, p. 429-433 5 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Fabrication of biodegradable PEG–PLA nanospheres for solubility, stabilization, and delivery of curcumin
Liang, H., Friedman, J. M. & Nacharaju, P., Feb 17 2017, In: Artificial Cells, Nanomedicine and Biotechnology. 45, 2, p. 297-304 8 p.Research output: Contribution to journal › Article › peer-review
Open Access45 Scopus citations -
Mechanistic Analysis of Fluorescence Quenching of Reduced Nicotinamide Adenine Dinucleotide by Oxamate in Lactate Dehydrogenase Ternary Complexes
Peng, H. L. & Callender, R., Oct 2017, In: Photochemistry and Photobiology. 93, 5, p. 1193-1203 11 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Nanoparticle Delivery of Fidgetin siRNA as a Microtubule-based Therapy to Augment Nerve Regeneration
Austin, T. O., Matamoros, A. J., Friedman, J. M., Friedman, A. J., Nacharaju, P., Yu, W., Sharp, D. J. & Baas, P. W., Dec 1 2017, In: Scientific reports. 7, 1, 9675.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Polyethylene glycol camouflaged earthworm hemoglobin
Jani, V. P., Jelvani, A., Moges, S., Nacharaju, P., Roche, C., Dantsker, D., Palmer, A., Friedman, J. M. & Cabrales, P., Jan 2017, In: PloS one. 12, 1, 0170041.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Reaction intermediates in the heme degradation reaction by HutZ from: Vibrio cholerae
Uchida, T., Sekine, Y., Dojun, N., Lewis-Ballester, A., Ishigami, I., Matsui, T., Yeh, S. R. & Ishimori, K., 2017, In: Dalton Transactions. 46, 25, p. 8104-8109 6 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase
Lewis-Ballester, A., Pham, K. N., Batabyal, D., Karkashon, S., Bonanno, J. B., Poulos, T. L. & Yeh, S. R., Dec 1 2017, In: Nature communications. 8, 1, 1693.Research output: Contribution to journal › Article › peer-review
Open Access116 Scopus citations -
The human Krebs cycle 2-oxoglutarate dehydrogenase complex creates an additional source of superoxide/hydrogen peroxide from 2-oxoadipate as alternative substrate
Nemeria, N. S., Gerfen, G., Guevara, E., Nareddy, P. R., Szostak, M. & Jordan, F., Jul 1 2017, In: Free Radical Biology and Medicine. 108, p. 644-654 11 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Topical nitric oxide releasing nanoparticles are effective in a murine model of dermal Trichophyton rubrum dermatophytosis
Mordorski, B., Costa-Orlandi, C. B., Baltazar, L. M., Carreño, L. J., Landriscina, A., Rosen, J., Navati, M., Mendes-Giannini, M. J. S., Friedman, J. M., Nosanchuk, J. D. & Friedman, A. J., Oct 2017, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 13, 7, p. 2267-2270 4 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
2016
A Comparative Analysis of the Effector Role of Redox Partner Binding in Bacterial P450s
Batabyal, D., Lewis-Ballester, A., Yeh, S. R. & Poulos, T. L., Nov 29 2016, In: Biochemistry. 55, 47, p. 6517-6523 7 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Antagonistic effect of atorvastatin on high fat diet induced survival during acute Chagas disease
Zhao, D., Lizardo, K., Cui, M. H., Ambadipudi, K., Lora, J., Jelicks, L. A. & Nagajyothi, J. F., Nov 1 2016, In: Microbes and Infection. 18, 11, p. 675-686 12 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model
Zhang, Z., Leong, D. J., Xu, L., He, Z., Wang, A., Navati, M., Kim, S. J., Hirsh, D. M., Hardin, J. A., Cobelli, N. J., Friedman, J. M. & Sun, H. B., Jun 3 2016, In: Arthritis Research and Therapy. 18, 1, 128.Research output: Contribution to journal › Article › peer-review
Open Access141 Scopus citations -
Distinct Interaction Modes of the Kinesin-13 Motor Domain with the Microtubule
Chatterjee, C., Benoit, M. P. M. H., DePaoli, V., Diaz-Valencia, J. D., Asenjo, A. B., Gerfen, G. J., Sharp, D. J. & Sosa, H., Apr 12 2016, In: Biophysical journal. 110, 7, p. 1593-1604 12 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase
Lewis-Ballester, A., Forouhar, F., Kim, S. M., Lew, S., Wang, Y., Karkashon, S., Seetharaman, J., Batabyal, D., Chiang, B. Y., Hussain, M., Correia, M. A., Yeh, S. R. & Tong, L., Oct 20 2016, In: Scientific reports. 6, 35169.Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1
Malachowski, W. P., Winters, M., DuHadaway, J. B., Lewis-Ballester, A., Badir, S., Wai, J., Rahman, M., Sheikh, E., LaLonde, J. M., Yeh, S. R., Prendergast, G. C. & Muller, A. J., Jan 27 2016, In: European Journal of Medicinal Chemistry. 108, p. 564-576 13 p.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations -
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
Briggs, KJ. J., Koivunen, P., Cao, S., Backus, KM. M., Olenchock, BA. A., Patel, H., Zhang, Q., Signoretti, S., Gerfen, GJ. J., Richardson, AL. L., Witkiewicz, AK. K., Cravatt, BF. F., Clardy, J. & Kaelin, WG. G., Jun 30 2016, In: Cell. 166, 1, p. 126-139 14 p.Research output: Contribution to journal › Article › peer-review
Open Access160 Scopus citations -
Structural Study of a Flexible Active Site Loop in Human Indoleamine 2,3-Dioxygenase and Its Functional Implications
Álvarez, L., Lewis-Ballester, A., Roitberg, A., Estrin, D. A., Yeh, S. R., Marti, M. A. & Capece, L., May 17 2016, In: Biochemistry. 55, 19, p. 2785-2793 9 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Topography of the TH5 Segment in the Diphtheria Toxin T-Domain Channel
Kienker, P. K., Wu, Z. & Finkelstein, A., Apr 1 2016, In: Journal of Membrane Biology. 249, 1-2, p. 181-196 16 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Trehalose-Based Glassy Matrices as an Effective Tool to Trap Short-Lived Intermediates in the Nitric Oxide Dioxygenation (NOD) Reaction of Hemoglobin
Navati, M. S., Chung, W. & Friedman, J. M., May 26 2016, In: Journal of Physical Chemistry B. 120, 20, p. 4529-4539 11 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
2015
Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent
Krausz, A. E., Adler, B. L., Cabral, V., Navati, M., Doerner, J., Charafeddine, R. A., Chandra, D., Liang, H., Gunther, L., Clendaniel, A., Harper, S., Friedman, J. M., Nosanchuk, J. D. & Friedman, A. J., Jan 1 2015, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 11, 1, p. 195-206 12 p.Research output: Contribution to journal › Article › peer-review
Open Access383 Scopus citations -
Evaluating the capacity to generate and preserve nitric oxide bioactivity in highly purified earthworm erythrocruorin: A giant polymeric hemoglobin with potential blood substitute properties
Roche, C. J., Talwar, A., Palmer, A. F., Cabrales, P., Gerfen, G. & Friedman, J. M., Jan 2 2015, In: Journal of Biological Chemistry. 290, 1, p. 99-117 19 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Fidgetin-Like 2: A Microtubule-Based Regulator of Wound Healing
Charafeddine, R. A., Makdisi, J., Schairer, D., O'Rourke, B. P., Diaz-Valencia, J. D., Chouake, J., Kutner, A., Krausz, A., Adler, B., Nacharaju, P., Liang, H., Mukherjee, S., Friedman, J. M., Friedman, A., Nosanchuk, J. D. & Sharp, D. J., Sep 18 2015, In: Journal of Investigative Dermatology. 135, 9, p. 2309-2318 10 p.Research output: Contribution to journal › Article › peer-review
Open Access49 Scopus citations