Fabrication of biodegradable PEG–PLA nanospheres for solubility, stabilization, and delivery of curcumin

Hongying Liang; Joel M. Friedman; Parimala Nacharaju

doi:10.3109/21691401.2016.1146736

Fabrication of biodegradable PEG–PLA nanospheres for solubility, stabilization, and delivery of curcumin

Hongying Liang, Joel M. Friedman, Parimala Nacharaju

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Curcumin is an effective and safe anticancer agent, and also known to induce vasodilation, but its hydrophobicity limits its clinical application. In this study, a simple emulsion method was developed to prepare biodegradable poly (ethylene glycol)–poly (lactic acid) (PEG–PLA) nanospheres to encapsulate curcumin to improve its solubility and stability. The nanoparticle size was around 150 nm with a narrow size distribution. Fluorescence microscopy showed that curcumin encapsulated PEG-PLA nanospheres were taken up rapidly by Hela and MDA-MB-231 cancer cells. This novel nanoparticulate carrier may improve the bioavailability of curcumin without affecting its anticancer properties.

Original language	English (US)
Pages (from-to)	297-304
Number of pages	8
Journal	Artificial Cells, Nanomedicine and Biotechnology
Volume	45
Issue number	2
DOIs	https://doi.org/10.3109/21691401.2016.1146736
State	Published - Feb 17 2017

Keywords

Curcumin
drug delivery
nanospheres
poly(ethylene glycol)–poly(lactic acid)

ASJC Scopus subject areas

Biotechnology
Medicine (miscellaneous)
Biomedical Engineering
Pharmaceutical Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/21691401.2016.1146736

Cite this

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abstract = "Curcumin is an effective and safe anticancer agent, and also known to induce vasodilation, but its hydrophobicity limits its clinical application. In this study, a simple emulsion method was developed to prepare biodegradable poly (ethylene glycol)–poly (lactic acid) (PEG–PLA) nanospheres to encapsulate curcumin to improve its solubility and stability. The nanoparticle size was around 150 nm with a narrow size distribution. Fluorescence microscopy showed that curcumin encapsulated PEG-PLA nanospheres were taken up rapidly by Hela and MDA-MB-231 cancer cells. This novel nanoparticulate carrier may improve the bioavailability of curcumin without affecting its anticancer properties.",

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AU - Friedman, Joel M.

AU - Nacharaju, Parimala

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AB - Curcumin is an effective and safe anticancer agent, and also known to induce vasodilation, but its hydrophobicity limits its clinical application. In this study, a simple emulsion method was developed to prepare biodegradable poly (ethylene glycol)–poly (lactic acid) (PEG–PLA) nanospheres to encapsulate curcumin to improve its solubility and stability. The nanoparticle size was around 150 nm with a narrow size distribution. Fluorescence microscopy showed that curcumin encapsulated PEG-PLA nanospheres were taken up rapidly by Hela and MDA-MB-231 cancer cells. This novel nanoparticulate carrier may improve the bioavailability of curcumin without affecting its anticancer properties.

KW - Curcumin

KW - drug delivery

KW - nanospheres

KW - poly(ethylene glycol)–poly(lactic acid)

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Fabrication of biodegradable PEG–PLA nanospheres for solubility, stabilization, and delivery of curcumin

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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