Nitric oxide-loaded nano- and microparticle platforms serving as potential new antifungal therapeutics

Sichen Liu, Daniel Zamith-Miranda, Rodrigo Almeida-Paes, Leandro Buffoni Roque da Silva, Parimala Nacharaju, Joshua D. Nosanchuk

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Fungal diseases are a leading threat to human health, especially in individuals with compromised immunity. Although there have been recent important advances in antifungal drug development, antifungal resistance, drug–drug interactions and difficulties in delivery remain major challenges. Among its pleiotropic actions, nitric oxide (NO) is a key molecule in host defense. We have developed a flexible nanoparticle platform that delivers sustained release of NO and have demonstrated the platform's efficacy against diverse bacteria as well as some fungal species. In this work, we investigate the effects of two NO-releasing particles against a panel of important human yeast. Our results demonstrate that the compounds are both effective against diverse yeast, including ascomycota and basidiomycota species, and that NO-releasing particles may be a potent addition to our armamentarium for the treatment of focal and disseminated mycoses.

Original languageEnglish (US)
Pages (from-to)1224-1230
Number of pages7
JournalFungal Biology
Volume127
Issue number7-8
DOIs
StatePublished - Jul 1 2023

Keywords

  • Candida
  • Cryptococcus
  • Drug discovery
  • Medical mycology
  • Novel

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Infectious Diseases

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