TY - JOUR
T1 - Nitric oxide-loaded nano- and microparticle platforms serving as potential new antifungal therapeutics
AU - Liu, Sichen
AU - Zamith-Miranda, Daniel
AU - Almeida-Paes, Rodrigo
AU - da Silva, Leandro Buffoni Roque
AU - Nacharaju, Parimala
AU - Nosanchuk, Joshua D.
N1 - Funding Information:
This article is part of the “Fungal growth, development, and stress responses” special issue for the XIII International Fungal Biology Conference (IFBC) & IV International Symposium on Fungal Stress (ISFUS) , which is supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) grant 2021/13614-3 and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) grant 88887.680665/2022-00 . J.D.N. and D.Z.M. were partially supported by NIH R21 AI156104-01 . R.A.P. was partially supported by Programa Jovens Pesquisadores ( INI /Fiocruz), grant number INI-003-FIO-19-2-7 , and CAPES 88887.372494/2019–00 . L.B.R.S. was supported by BEPE FAPESP 2019/20622-2 .
Publisher Copyright:
© 2023
PY - 2023
Y1 - 2023
N2 - Fungal diseases are a leading threat to human health, especially in individuals with compromised immunity. Although there have been recent important advances in antifungal drug development, antifungal resistance, drug–drug interactions and difficulties in delivery remain major challenges. Among its pleiotropic actions, nitric oxide (NO) is a key molecule in host defense. We have developed a flexible nanoparticle platform that delivers sustained release of NO and have demonstrated the platform's efficacy against diverse bacteria as well as some fungal species. In this work, we investigate the effects of two NO-releasing particles against a panel of important human yeast. Our results demonstrate that the compounds are both effective against diverse yeast, including ascomycota and basidiomycota species, and that NO-releasing particles may be a potent addition to our armamentarium for the treatment of focal and disseminated mycoses.
AB - Fungal diseases are a leading threat to human health, especially in individuals with compromised immunity. Although there have been recent important advances in antifungal drug development, antifungal resistance, drug–drug interactions and difficulties in delivery remain major challenges. Among its pleiotropic actions, nitric oxide (NO) is a key molecule in host defense. We have developed a flexible nanoparticle platform that delivers sustained release of NO and have demonstrated the platform's efficacy against diverse bacteria as well as some fungal species. In this work, we investigate the effects of two NO-releasing particles against a panel of important human yeast. Our results demonstrate that the compounds are both effective against diverse yeast, including ascomycota and basidiomycota species, and that NO-releasing particles may be a potent addition to our armamentarium for the treatment of focal and disseminated mycoses.
KW - Candida
KW - Cryptococcus
KW - Drug discovery
KW - Medical mycology
KW - Novel
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U2 - 10.1016/j.funbio.2023.01.007
DO - 10.1016/j.funbio.2023.01.007
M3 - Article
AN - SCOPUS:85151297991
SN - 1878-6146
JO - Mycological Research
JF - Mycological Research
ER -
