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Nir Barzilai, M.D.

Calculated based on number of publications stored in Pure and citations from Scopus
Calculated based on number of publications stored in Pure and citations from Scopus
Calculated based on number of publications stored in Pure and citations from Scopus
1985 …2024

Research activity per year

Search results

  • 2020

    Benefits of Metformin in Attenuating the Hallmarks of Aging

    Kulkarni, A. S., Gubbi, S. & Barzilai, N., Jul 7 2020, In: Cell metabolism. 32, 1, p. 15-30 16 p.

    Research output: Contribution to journal › Review article › peer-review

    Open Access
    369 Scopus citations

  • Genetics of extreme human longevity to guide drug discovery for healthy ageing

    Zhang, Z. D., Milman, S., Lin, J. R., Wierbowski, S., Yu, H., Barzilai, N., Gorbunova, V., Ladiges, W. C., Niedernhofer, L. J., Suh, Y., Robbins, P. D. & Vijg, J., Aug 1 2020, In: Nature Metabolism. 2, 8, p. 663-672 10 p.

    Research output: Contribution to journal › Review article › peer-review

    Open Access
    32 Scopus citations

  • Geroscience in the age of COVID-19

    Barzilai, N., Appleby, J. C., Austad, S. N., Cuervo, A. M., Kaeberlein, M., Gonzalez-Billault, C., Lederman, S., Stambler, I. & Sierra, F., 2020, In: Aging and Disease. 11, 4, p. 725-729 5 p.

    Research output: Contribution to journal › Review article › peer-review

    Open Access
    22 Scopus citations

  • Insulin-like Growth Factor-1 and IGF Binding Proteins Predict All-Cause Mortality and Morbidity in Older Adults

    Zhang, W. B., Aleksic, S., Gao, T., Weiss, E. F., Demetriou, E., Verghese, J., Holtzer, R., Barzilai, N. & Milman, S., Jun 1 2020, In: Cells. 9, 6, 1364.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    29 Scopus citations

  • Metformin alters skeletal muscle transcriptome adaptations to resistance training in older adults

    Kulkarni, A. S., Peck, B. D., Walton, R. G., Kern, P. A., Mar, J. C., Windham, S. T., Bamman, M. M., Barzilai, N. & Peterson, C. A., Oct 18 2020, In: Aging. 12, 20, p. 19852-19866 15 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    21 Scopus citations

  • Plasma proteomic profile of age, health span, and all-cause mortality in older adults

    Sathyan, S., Ayers, E., Gao, T., Weiss, E. F., Milman, S., Verghese, J. & Barzilai, N., Nov 2020, In: Aging cell. 19, 11, e13250.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    44 Scopus citations

  • Plasma proteomic profile of frailty

    Sathyan, S., Ayers, E., Gao, T., Milman, S., Barzilai, N. & Verghese, J., Sep 1 2020, In: Aging cell. 19, 9, e13193.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    27 Scopus citations

  • Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A

    Rozanov, L., Ravichandran, M., Grigolon, G., Zanellati, M. C., Mansfeld, J., Zarse, K., Barzilai, N., Atzmon, G., Fischer, F. & Ristow, M., May 2020, In: Redox Biology. 32, 101448.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    10 Scopus citations

  • Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity

    Regeneron Genetics Center, Oct 1 2020, In: Aging cell. 19, 10, e13216.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    7 Scopus citations

  • The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan

    Yen, K., Mehta, H. H., Kim, S. J., Lue, Y. H., Hoang, J., Guerrero, N., Port, J., Bi, Q., Navarrete, G., Brandhorst, S., Lewis, K. N., Wan, J., Swerdloff, R., Mattison, J. A., Buffenstein, R., Breton, C. V., Wang, C., Long, V., Atzmon, G., Wallace, D., & 2 othersBarzilai, N. & Cohen, P., Jun 30 2020, In: Aging. 12, 12, p. 11185-11199 15 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    68 Scopus citations
  • 2019

    A meta-analysis of genome-wide association studies identifies multiple longevity genes

    Deelen, J., Evans, D. S., Arking, D. E., Tesi, N., Nygaard, M., Liu, X., Wojczynski, M. K., Biggs, M. L., van der Spek, A., Atzmon, G., Ware, E. B., Sarnowski, C., Smith, A. V., Seppälä, I., Cordell, H. J., Dose, J., Amin, N., Arnold, A. M., Ayers, K. L., Barzilai, N., & 64 othersBecker, E. J., Beekman, M., Blanché, H., Christensen, K., Christiansen, L., Collerton, J. C., Cubaynes, S., Cummings, S. R., Davies, K., Debrabant, B., Deleuze, J. F., Duncan, R., Faul, J. D., Franceschi, C., Galan, P., Gudnason, V., Harris, T. B., Huisman, M., Hurme, M. A., Jagger, C., Jansen, I., Jylhä, M., Kähönen, M., Karasik, D., Kardia, S. L. R., Kingston, A., Kirkwood, T. B. L., Launer, L. J., Lehtimäki, T., Lieb, W., Lyytikäinen, L. P., Martin-Ruiz, C., Min, J., Nebel, A., Newman, A. B., Nie, C., Nohr, E. A., Orwoll, E. S., Perls, T. T., Province, M. A., Psaty, B. M., Raitakari, O. T., Reinders, M. J. T., Robine, J. M., Rotter, J. I., Sebastiani, P., Smith, J., Sørensen, T. I. A., Taylor, K. D., Uitterlinden, A. G., van der Flier, W., van der Lee, S. J., van Duijn, C. M., van Heemst, D., Vaupel, J. W., Weir, D., Ye, K., Zeng, Y., Zheng, W., Holstege, H., Kiel, D. P., Lunetta, K. L., Slagboom, P. E. & Murabito, J. M., Dec 1 2019, In: Nature communications. 10, 1, 3669.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    190 Scopus citations

  • APOE Alleles and extreme human longevity

    Sebastiani, P., Gurinovich, A., Nygaard, M., Sasaki, T., Sweigart, B., Bae, H., Andersen, S. L., Villa, F., Atzmon, G., Christensen, K., Arai, Y., Barzilai, N., Puca, A., Christiansen, L., Hirose, N. & Perls, T. T., Jan 1 2019, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 1, p. 44-51 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    80 Scopus citations

  • Chronic inflammation in the etiology of disease across the life span

    Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., Miller, A. H., Mantovani, A., Weyand, C. M., Barzilai, N., Goronzy, J. J., Rando, T. A., Effros, R. B., Lucia, A., Kleinstreuer, N. & Slavich, G. M., Dec 1 2019, In: Nature Medicine. 25, 12, p. 1822-1832 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    2139 Scopus citations

  • Correction: Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population (PLOS Genetics, (2018), 14, 5, 10.1371/journal.pgen.1007329)

    International IBD Genetics Consortium, NIDDK IBD Genetics Consortium & T2D-GENES Consortium, May 2019, In: PLoS genetics. 15, 5, e1008190.

    Research output: Contribution to journal › Comment/debate › peer-review

    Open Access
    3 Scopus citations

  • Creating the Next Generation of Translational Geroscientists

    Newman, J. C., Sokoloski, J. L., Robbins, P. D., Niedernhofer, L. J., Reed, M. J., Wei, J., Austad, S. N., Barzilai, N., Cohen, H. J., Kuchel, G. A., Kirkland, J. L. & Pignolo, R. J., Sep 1 2019, In: Journal of the American Geriatrics Society. 67, 9, p. 1934-1939 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    12 Scopus citations

  • Empirical design of a variant quality control pipeline for whole genome sequencing data using replicate discordance

    Adelson, R. P., Renton, A. E., Li, W., Barzilai, N., Atzmon, G., Goate, A. M., Davies, P. & Freudenberg-Hua, Y., Dec 1 2019, In: Scientific reports. 9, 1, 16156.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    8 Scopus citations

  • Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

    Broad Genomics Platform, DiscovEHR Collaboration, CHARGE, LuCamp, ProDiGY, GoT2D, ESP, SIGMA-T2D, T2D-GENES & AMP-T2D-GENES, Jun 6 2019, In: Nature. 570, 7759, p. 71-76 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    190 Scopus citations

  • Frailty and Risk of Incident Motoric Cognitive Risk Syndrome

    Sathyan, S., Ayers, E., Gao, T., Milman, S., Barzilai, N., Rockwood, K. & Verghese, J., 2019, In: Journal of Alzheimer's Disease. 71, s1, p. S85-S93

    Research output: Contribution to journal › Article › peer-review

    Open Access
    27 Scopus citations

  • Interrogating the genetic determinants of Tourette's syndrome and other tiC disorders through genome-wide association studies

    Tourette Association of America International Consortium for Genetics, Gilles de la Tourette GWAS Replication Initiative, Tourette International Collaborative Genetics Study & Psychiatric Genomics Consortium Tourette Syndrome Working Group, Mar 1 2019, In: American Journal of Psychiatry. 176, 3, p. 217-227 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    170 Scopus citations

  • Latest advances in aging research and drug discovery

    Bakula, D., Ablasser, A., Aguzzi, A., Antebi, A., Barzilai, N., Bittner, M. I., Jensen, M. B., Calkhoven, C. F., Chen, D., de Grey, A. D. N. J., Feige, J. N., Georgievskaya, A., Gladyshev, V. N., Golato, T., Gudkov, A. V., Hoppe, T., Kaeberlein, M., Katajisto, P., Kennedy, B. K., Lal, U., & 10 othersMartin-Villalba, A., Moskalev, A. A., Ozerov, I., Petr, M. A., Reason, Rubinsztein, D. C., Tyshkovskiy, A., Vanhaelen, Q., Zhavoronkov, A. & Scheibye-Knudsen, M., 2019, In: Aging. 11, 22, p. 9971-9981 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    15 Scopus citations

  • Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series

    Hurria, A., Carpenter, C. R., McFarland, F., Lundebjerg, N. E., de Cabo, R., Ferrucci, L., Studenski, S. A., Barzilai, N., Briggs, J. P., Ix, J. H., Kitzman, D. W., Kuchel, G. A., Musi, N., Newman, J. C., Rando, T. A., Smith, A. K., Walston, J. D., Kirkland, J. L. & Yung, R., Mar 2019, In: Journal of the American Geriatrics Society. 67, 3, p. 428-433 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    12 Scopus citations

  • PopCluster: An algorithm to identify genetic variants with ethnicity-dependent effects

    Gurinovich, A., Bae, H., Farrell, J. J., Andersen, S. L., Monti, S., Puca, A., Atzmon, G., Barzilai, N., Perls, T. T. & Sebastiani, P., Sep 1 2019, In: Bioinformatics. 35, 17, p. 3046-3054 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    3 Scopus citations

  • Screening Human Embryos for Polygenic Traits Has Limited Utility

    Karavani, E., Zuk, O., Zeevi, D., Barzilai, N., Stefanis, N. C., Hatzimanolis, A., Smyrnis, N., Avramopoulos, D., Kruglyak, L., Atzmon, G., Lam, M., Lencz, T. & Carmi, S., Nov 27 2019, In: Cell. 179, 6, p. 1424-1435.e8

    Research output: Contribution to journal › Article › peer-review

    Open Access
    58 Scopus citations

  • Undulating changes in human plasma proteome profiles across the lifespan

    Lehallier, B., Gate, D., Schaum, N., Nanasi, T., Lee, S. E., Yousef, H., Moran Losada, P., Berdnik, D., Keller, A., Verghese, J., Sathyan, S., Franceschi, C., Milman, S., Barzilai, N. & Wyss-Coray, T., Dec 1 2019, In: Nature Medicine. 25, 12, p. 1843-1850 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    383 Scopus citations

  • Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities

    Gurinovich, A., Andersen, S. L., Puca, A., Atzmon, G., Barzilai, N. & Sebastiani, P., Nov 13 2019, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, p. S45-S51

    Research output: Contribution to journal › Article › peer-review

    Open Access
    12 Scopus citations
  • 2018

    40 years of IGF1: IGF1: The Jekyll and Hyde of the aging brain

    Gubbi, S., Quipildor, G. F., Barzilai, N., Huffman, D. M. & Milman, S., Jul 2018, In: Journal of Molecular Endocrinology. 61, 1, p. T171-T185

    Research output: Contribution to journal › Review article › peer-review

    Open Access
    67 Scopus citations

  • A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup

    Justice, J. N., Ferrucci, L., Newman, A. B., Aroda, V. R., Bahnson, J. L., Divers, J., Espeland, M. A., Marcovina, S., Pollak, M. N., Kritchevsky, S. B., Barzilai, N. & Kuchel, G. A., Dec 1 2018, In: GeroScience. 40, 5-6, p. 419-436 18 p.

    Research output: Contribution to journal › Review article › peer-review

    Open Access
    192 Scopus citations

  • Aging as a Biological Target for Prevention and Therapy

    Barzilai, N., Cuervo, A. M. & Austad, S., Oct 2 2018, In: JAMA - Journal of the American Medical Association. 320, 13, p. 1321-1322 2 p.

    Research output: Contribution to journal › Review article › peer-review

    74 Scopus citations

  • Aging health and R & D for healthy longevity must be included into the WHO work program

    Stambler, I., Jin, K., Lederman, S., Barzilai, N., Jay Olshansky, S., Omokaro, E., Barratt, J., Anisimov, V. N., Rattan, S., Yang, S., Forster, M. & Byles, J., Apr 1 2018, In: Aging and Disease. 9, 2, p. 331-333 3 p.

    Research output: Contribution to journal › Editorial › peer-review

    Open Access
    15 Scopus citations

  • Development of clinical trials to extend healthy lifespan

    Justice, J. N., Niedernhofer, L., Robbins, P. D., Aroda, V. R., Espeland, M. A., Kritchevsky, S. B., Kuchel, G. A. & Barzilai, N., Dec 1 2018, In: Cardiovascular Endocrinology and Metabolism. 7, 4, p. 80-83 4 p.

    Research output: Contribution to journal › Review article › peer-review

    Open Access
    53 Scopus citations

  • Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies

    Bae, H., Gurinovich, A., Malovini, A., Atzmon, G., Andersen, S. L., Villa, F., Barzilai, N., Puca, A., Perls, T. T. & Sebastiani, P., Oct 8 2018, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 11, p. 1439-1447 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    25 Scopus citations

  • Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

    Flannick, J., Fuchsberger, C., Mahajan, A., Teslovich, T. M., Agarwala, V., Gaulton, K. J., Caulkins, L., Koesterer, R., Ma, C., Moutsianas, L., McCarthy, D. J., Rivas, M. A., Perry, J. R. B., Sim, X., Blackwell, T. W., Robertson, N. R., Rayner, N. W., Cingolani, P., Locke, A. E., Tajes, J. F., & 281 othersHighland, H. M., Dupuis, J., Chines, P. S., Lindgren, C. M., Hartl, C., Jackson, A. U., Chen, H., Huyghe, J. R., van de Bunt, M., Pearson, R. D., Kumar, A., Müller-Nurasyid, M., Grarup, N., Stringham, H. M., Gamazon, E. R., Lee, J., Chen, Y., Scott, R. A., Below, J. E., Chen, P., Huang, J., Go, M. J., Stitzel, M. L., Pasko, D., Parker, S. C. J., Varga, T. V., Green, T., Beer, N. L., Day-Williams, A. G., Ferreira, T., Fingerlin, T., Horikoshi, M., Hu, C., Huh, I., Ikram, M. K., Kim, B. J., Kim, Y., Kim, Y. J., Kwon, M. S., Lee, J., Lee, S., Lin, K. H., Maxwell, T. J., Nagai, Y., Wang, X., Welch, R. P., Yoon, J., Zhang, W., Barzilai, N., Voight, B. F., Han, B. G., Jenkinson, C. P., Kuulasmaa, T., Kuusisto, J., Manning, A., Ng, M. C. Y., Palmer, N. D., Balkau, B., Stančáková, A., Abboud, H. E., Boeing, H., Giedraitis, V., Prabhakaran, D., Gottesman, O., Scott, J., Carey, J., Kwan, P., Grant, G., Smith, J. D., Neale, B. M., Purcell, S., Butterworth, A. S., Howson, J. M. M., Lee, H. M., Lu, Y., Kwak, S. H., Zhao, W., Danesh, J., Lam, V. K. L., Park, K. S., Saleheen, D., So, W. Y., Tam, C. H. T., Afzal, U., Aguilar, D., Arya, R., Aung, T., Chan, E., Navarro, C., Cheng, C. Y., Palli, D., Correa, A., Curran, J. E., Rybin, D., Farook, V. S., Fowler, S. P., Freedman, B. I., Griswold, M., Hale, D. E., Hicks, P. J., Khor, C. C., Kumar, S., Lehne, B., Thuillier, D., Lim, W. Y., Liu, J., Loh, M., Musani, S. K., Puppala, S., Scott, W. R., Yengo, L., Tan, S. T., Taylor, H. A., Thameem, F., Wilson, G., Wong, T. Y., Njølstad, P. R., Levy, J. C., Mangino, M., Bonnycastle, L. L., Schwarzmayr, T., Fadista, J., Surdulescu, G. L., Herder, C., Groves, C. J., Wieland, T., Bork-Jensen, J., Brandslund, I., Christensen, C., Koistinen, H. A., Doney, A. S. F., Kinnunen, L., Esko, T., Farmer, A. J., Hakaste, L., Hodgkiss, D., Kravic, J., Lyssenko, V., Hollensted, M., Jørgensen, M. E., Jørgensen, T., Ladenvall, C., Justesen, J. M., Käräjämäki, A., Kriebel, J., Rathmann, W., Lannfelt, L., Lauritzen, T., Narisu, N., Linneberg, A., Melander, O., Milani, L., Neville, M., Orho-Melander, M., Qi, L., Qi, Q., Roden, M., Rolandsson, O., Swift, A., Rosengren, A. H., Stirrups, K., Wood, A. R., Mihailov, E., Blancher, C., Carneiro, M. O., Maguire, J., Poplin, R., Shakir, K., Fennell, T., DePristo, M., de Angelis, M. H., Deloukas, P., Gjesing, A. P., Jun, G., Nilsson, P., Murphy, J., Onofrio, R., Thorand, B., Hansen, T., Meisinger, C., Hu, F. B., Isomaa, B., Karpe, F., Liang, L., Peters, A., Huth, C., O'Rahilly, S. P., Palmer, C. N. A., Pedersen, O., Rauramaa, R., Tuomilehto, J., Salomaa, V., Watanabe, R. M., Syvänen, A. C., Bergman, R. N., Bharadwaj, D., Bottinger, E. P., Cho, Y. S., Chandak, G. R., Chan, J. C. N., Chia, K. S., Daly, M. J., Ebrahim, S. B., Langenberg, C., Elliott, P., Jablonski, K. A., Lehman, D. M., Jia, W., Ma, R. C. W., Pollin, T. I., Sandhu, M., Tandon, N., Froguel, P., Barroso, I., Teo, Y. Y., Zeggini, E., Loos, R. J. F., Small, K. S., Ried, J. S., DeFronzo, R. A., Grallert, H., Glaser, B., Metspalu, A., Wareham, N. J., Walker, M., Banks, E., Gieger, C., Ingelsson, E., Im, H. K., Illig, T., Franks, P. W., Buck, G., Trakalo, J., Buck, D., Prokopenko, I., Mägi, R., Lind, L., Farjoun, Y., Owen, K. R., Gloyn, A. L., Strauch, K., Tuomi, T., Kooner, J. S., Lee, J. Y., Park, T., Donnelly, P., Morris, A. D., Hattersley, A. T., Bowden, D. W., Collins, F. S., Atzmon, G., Chambers, J. C., Spector, T. D., Laakso, M., Strom, T. M., Bell, G. I., Blangero, J., Duggirala, R., Tai, E. S., McVean, G., Hanis, C. L., Wilson, J. G., Seielstad, M., Frayling, T. M., Meigs, J. B., Cox, N. J., Sladek, R., Lander, E. S., Gabriel, S., Mohlke, K. L., Meitinger, T., Groop, L., Abecasis, G., Scott, L. J., Morris, A. P., Kang, H. M., Altshuler, D., Burtt, N. P., Florez, J. C., Boehnke, M. & McCarthy, M. I., Jan 23 2018, In: Scientific Data. 5, p. 180002 1 p.

    Research output: Contribution to journal › Comment/debate › peer-review

    Open Access
    1 Scopus citations

  • Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease

    Hui, K. Y., Fernandez-Hernandez, H., Hu, J., Schaffner, A., Pankratz, N., Hsu, N. Y., Chuang, L. S., Carmi, S., Villaverde, N., Li, X., Rivas, M., Levine, A. P., Bao, X., Labrias, P. R., Haritunians, T., Ruane, D., Gettler, K., Chen, E., Li, D., Schiff, E. R., & 31 othersPontikos, N., Barzilai, N., Brant, S. R., Bressman, S., Cheifetz, A. S., Clark, L. N., Daly, M. J., Desnick, R. J., Duerr, R. H., Katz, S., Lencz, T., Myers, R. H., Ostrer, H., Ozelius, L., Payami, H., Peter, Y., Rioux, J. D., Segal, A. W., Scott, W. K., Silverberg, M. S., Vance, J. M., Ubarretxena-Belandia, I., Foroud, T., Atzmon, G., Pe'er, I., Ioannou, Y., McGovern, D. P. B., Yue, Z., Schadt, E. E., Cho, J. H. & Peter, I., Jan 10 2018, In: Science translational medicine. 10, 423, eaai7795.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    243 Scopus citations

  • Genetic insights into frailty: Association of 9p21-23 locus with frailty

    Sathyan, S., Barzilai, N., Atzmon, G., Milman, S., Ayers, E. & Verghese, J., May 1 2018, In: Frontiers in Medicine. 5, MAY, 105.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    17 Scopus citations

  • High-depth whole genome sequencing of an Ashkenazi Jewish reference panel: enhancing sensitivity, accuracy, and imputation

    Lencz, T., Yu, J., Palmer, C., Carmi, S., Ben-Avraham, D., Barzilai, N., Bressman, S., Darvasi, A., Cho, J. H., Clark, L. N., Gümüş, Z. H., Joseph, V., Klein, R., Lipkin, S., Offit, K., Ostrer, H., Ozelius, L. J., Peter, I., Atzmon, G. & Pe’er, I., Apr 1 2018, In: Human Genetics. 137, 4, p. 343-355 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    17 Scopus citations

  • Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

    International IBD Genetics Consortium, NIDDK IBD Genetics Consortium & T2D-GENES Consortium, May 2018, In: PLoS genetics. 14, 5, e1007329.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    48 Scopus citations

  • Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice

    Mao, K., Quipildor, G. F., Tabrizian, T., Novaj, A., Guan, F., Walters, R. O., Delahaye, F., Hubbard, G. B., Ikeno, Y., Ejima, K., Li, P., Allison, D. B., Salimi-Moosavi, H., Beltran, P. J., Cohen, P., Barzilai, N. & Huffman, D. M., Dec 1 2018, In: Nature communications. 9, 1, 2394.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    94 Scopus citations

  • Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults

    Kulkarni, A. S., Brutsaert, E. F., Anghel, V., Zhang, K., Bloomgarden, N., Pollak, M., Mar, J. C., Hawkins, M., Crandall, J. P. & Barzilai, N., Apr 2018, In: Aging cell. 17, 2, e12723.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    107 Scopus citations

  • Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans

    Walters, R. O., Arias, E., Diaz, A., Burgos, E. S., Guan, F., Tiano, S., Mao, K., Green, C. L., Qiu, Y., Shah, H., Wang, D., Hudgins, A. D., Tabrizian, T., Tosti, V., Shechter, D., Fontana, L., Kurland, I. J., Barzilai, N., Cuervo, A. M., Promislow, D. E. L., & 1 othersHuffman, D. M., Oct 16 2018, In: Cell Reports. 25, 3, p. 663-676.e6

    Research output: Contribution to journal › Article › peer-review

    Open Access
    40 Scopus citations

  • Targeting senescence

    Serrano, M. & Barzilai, N., Aug 1 2018, In: Nature Medicine. 24, 8, p. 1092-1094 3 p.

    Research output: Contribution to journal › Article › peer-review

    18 Scopus citations
  • 2017

    Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity

    Raz, Y., Guerrero-Ros, I., Maier, A., Slagboom, P. E., Atzmon, G., Barzilai, N. & Macian, F., Sep 1 2017, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 72, 9, p. 1201-1206 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    36 Scopus citations

  • A low-frequency inactivating AKT2 variant enriched in the finnish population is associated with fasting insulin levels and type 2 diabetes risk

    Manning, A., Highland, H. M., Gasser, J., Sim, X., Tukiainen, T., Fontanillas, P., Grarup, N., Rivas, M. A., Mahajan, A., Locke, A. E., Cingolani, P., Pers, T. H., Viñuela, A., Brown, A. A., Wu, Y., Flannick, J., Fuchsberger, C., Gamazon, E. R., Gaulton, K. J., Im, H. K., & 243 othersTeslovich, T. M., Blackwell, T. W., Bork-Jensen, J., Burtt, N. P., Chen, Y., Green, T., Hartl, C., Kang, H. M., Kumar, A., Ladenvall, C., Ma, C., Moutsianas, L., Pearson, R. D., Perry, J. R. B., Rayner, N. W., Robertson, N. R., Scott, L. J., van de Bunt, M., Eriksson, J. G., Jula, A., Koskinen, S., Lehtimäki, T., Palotie, A., Raitakari, O. T., Jacobs, S. B. R., Wessel, J., Chu, A. Y., Scott, R. A., Goodarzi, M. O., Blancher, C., Buck, G., Buck, D., Chines, P. S., Gabriel, S., Gjesing, A. P., Groves, C. J., Hollensted, M., Huyghe, J. R., Jackson, A. U., Jun, G., Justesen, J. M., Mangino, M., Murphy, J., Neville, M., Onofrio, R., Small, K. S., Stringham, H. M., Trakalo, J., Banks, E., Carey, J., Carneiro, M. O., Depristo, M., Farjoun, Y., Fennell, T., Goldstein, J. I., Grant, G., de Angelis, M. H., Maguire, J., Neale, B. M., Poplin, R., Purcell, S., Schwarzmayr, T., Shakir, K., Smith, J. D., Strom, T. M., Wieland, T., Lindstrom, J., Brandslund, I., Christensen, C., Surdulescu, G. L., Lakka, T. A., Doney, A. S. F., Nilsson, P., Wareham, N. J., Langenberg, C., Varga, T. V., Franks, P. W., Rolandsson, O., Rosengren, A. H., Farook, V. S., Thameem, F., Puppala, S., Kumar, S., Lehman, D. M., Jenkinson, C. P., Curran, J. E., Hale, D. E., Fowler, S. P., Arya, R., Defronzo, R. A., Abboud, H. E., Syvänen, A. C., Hicks, P. J., Palmer, N. D., Ng, M. C. Y., Bowden, D. W., Freedman, B. I., Esko, T., Mägi, R., Milani, L., Mihailov, E., Metspalu, A., Narisu, N., Kinnunen, L., Bonnycastle, L. L., Swift, A., Pasko, D., Wood, A. R., Fadista, J., Pollin, T. I., Barzilai, N., Atzmon, G., Glaser, B., Thorand, B., Strauch, K., Peters, A., Roden, M., Müller-Nurasyid, M., Liang, L., Kriebel, J., Illig, T., Grallert, H., Gieger, C., Meisinger, C., Lannfelt, L., Musani, S. K., Griswold, M., Taylor, H. A., Wilson, G., Correa, A., Oksa, H., Scott, W. R., Afzal, U., Tan, S. T., Loh, M., Chambers, J. C., Sehmi, J., Kooner, J. S., Lehne, B., Cho, Y. S., Lee, J. Y., Han, B. G., Käräjämäki, A., Qi, Q., Qi, L., Huang, J., Hu, F. B., E Mel Ander, O. L., Orho-Melander, M., Below, J. E., Aguilar, D., Wong, T. Y., U, J. L., Khor, C. C., Chia, K. S., Lim, W. Y., Cheng, C. Y., Chan, E., Shyong Tai, E., Aung, T., Linneberg, A., Isomaa, B., Meitinger, T., Tuomi, T., Hakaste, L., Na Kravi C, J., Jørgensen, M. E., Lauritzen, T., Deloukas, P., Stirrups, K. E., Kat, K. H., Farmer, A. J., Frayling, T. M., O’rahilly, S. P., Walker, M., Levy, J. C., Hodgkiss, D., Hattersley, A. T., Kuulasmaa, T., Stan?cáková, A., Barroso, I., Bharadwaj, D., Chan, J., Chandak, G. R., Daly, M. J., Donnelly, P. J., Ebrahim, S. B., Elliott, P., Fingerlin, T., Froguel, P., Hu, C., Jia, W., Ma, R. C. W., McVean, G., Park, T., Prabhakaran, D., Sandhu, M., Scott, J., Sladek, R., Tandon, N., Teo, Y. Y., Zeggini, E., Watanabe, R. M., Koistinen, H. A., Antero Kesaniemi, Y., Uusitupa, M., Spector, T. D., Salomaa, V., Rauramaa, R., Palmer, C. N. A., Prokopenko, I., Morris, A. D., Bergman, R. N., Collins, F. S., Lind, L., Ingelsson, E., Tuomilehto, J., Karpe, F., Groop, L., Jørgensen, T., Hansen, T., Pedersen, O., Kuusisto, J., Abecasis, G., Bell, G. I., Blangero, J., Cox, N. J., Duggirala, R., Seielstad, M., Wilson, J. G., Dupuis, J., Ripatti, S., Hanis, C. L., Florez, J. C., Mohlke, K. L., Meigs, J. B., Laakso, M., Morris, A. P., Boehnke, M., Altshuler, D., McCarthy, M. I., Gloyn, A. L. & Lindgren, C. M., Jul 1 2017, In: Diabetes. 66, 7, p. 2019-2032 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    40 Scopus citations

  • Association between sleep patterns and health in families with exceptional longevity

    Klein, L., Gao, T., Barzilai, N. & Milman, S., 2017, In: Frontiers in Medicine. 4, DEC, 214.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    5 Scopus citations

  • Association of anti-inflammatory cytokine IL10 polymorphisms with motoric cognitive risk syndrome in an Ashkenazi Jewish population

    Sathyan, S., Barzilai, N., Atzmon, G., Milman, S., Ayers, E. & Verghese, J., Oct 2017, In: Neurobiology of Aging. 58, p. 238.e1-238.e8

    Research output: Contribution to journal › Article › peer-review

    Open Access
    19 Scopus citations

  • Association of Family History of Exceptional Longevity with Decline in Physical Function in Aging

    Ayers, E., Barzilai, N., Crandall, J. P., Milman, S. & Verghese, J., Nov 9 2017, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 72, 12, p. 1649-1655 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    10 Scopus citations

  • Clinical trials targeting aging and age-related multimorbidity

    Espeland, M. A., Crimmins, E. M., Grossardt, B. R., Crandall, J. P., Gelfond, J. A. L., Harris, T. B., Kritchevsky, S. B., Manson, J. E., Robinson, J. G., Rocca, W. A., Temprosa, M., Thomas, F., Wallace, R. & Barzilai, N., 2017, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 72, 3, p. 355-361 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    45 Scopus citations

  • Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

    Flannick, J., Fuchsberger, C., Mahajan, A., Teslovich, T. M., Agarwala, V., Gaulton, K. J., Caulkins, L., Koesterer, R., Ma, C., Moutsianas, L., McCarthy, D. J., Rivas, M. A., Perry, J. R. B., Sim, X., Blackwell, T. W., Robertson, N. R., Rayner, N. W., Cingolani, P., Locke, A. E., Tajes, J. F., & 281 othersHighland, H. M., Dupuis, J., Chines, P. S., Lindgren, C. M., Hartl, C., Jackson, A. U., Chen, H., Huyghe, J. R., Van De Bunt, M., Pearson, R. D., Kumar, A., Müller-Nurasyid, M., Grarup, N., Stringham, H. M., Gamazon, E. R., Lee, J., Chen, Y., Scott, R. A., Below, J. E., Chen, P., Huang, J., Go, M. J., Stitzel, M. L., Pasko, D., Parker, S. C. J., Varga, T. V., Green, T., Beer, N. L., Day-Williams, A. G., Ferreira, T., Fingerlin, T., Horikoshi, M., Hu, C., Huh, I., Ikram, M. K., Kim, B. J., Kim, Y., Kim, Y. J., Kwon, M. S., Lee, J., Lee, S., Lin, K. H., Maxwell, T. J., Nagai, Y., Wang, X., Welch, R. P., Yoon, J., Zhang, W., Barzilai, N., Voight, B. F., Han, B. G., Jenkinson, C. P., Kuulasmaa, T., Kuusisto, J., Manning, A., Ng, M. C. Y., Palmer, N. D., Balkau, B., Stančáková, A., Abboud, H. E., Boeing, H., Giedraitis, V., Prabhakaran, D., Gottesman, O., Scott, J., Carey, J., Kwan, P., Grant, G., Smith, J. D., Neale, B. M., Purcell, S., Butterworth, A. S., Howson, J. M. M., Lee, H. M., Lu, Y., Kwak, S. H., Zhao, W., Danesh, J., Lam, V. K. L., Park, K. S., Saleheen, D., So, W. Y., Tam, C. H. T., Afzal, U., Aguilar, D., Arya, R., Aung, T., Chan, E., Navarro, C., Cheng, C. Y., Palli, D., Correa, A., Curran, J. E., Rybin, D., Farook, V. S., Fowler, S. P., Freedman, B. I., Griswold, M., Hale, D. E., Hicks, P. J., Khor, C. C., Kumar, S., Lehne, B., Thuillier, D., Lim, W. Y., Liu, J., Loh, M., Musani, S. K., Puppala, S., Scott, W. R., Yengo, L., Tan, S. T., Taylor, H. A., Thameem, F., Wilson, G., Wong, T. Y., Njølstad, P. R., Levy, J. C., Mangino, M., Bonnycastle, L. L., Schwarzmayr, T., Fadista, J., Surdulescu, G. L., Herder, C., Groves, C. J., Wieland, T., Bork-Jensen, J., Brandslund, I., Christensen, C., Koistinen, H. A., Doney, A. S. F., Kinnunen, L., Esko, T., Farmer, A. J., Hakaste, L., Hodgkiss, D., Kravic, J., Lyssenko, V., Hollensted, M., Jørgensen, M. E., Jørgensen, T., Ladenvall, C., Justesen, J. M., Käräjämäki, A., Kriebel, J., Rathmann, W., Lannfelt, L., Lauritzen, T., Narisu, N., Linneberg, A., Melander, O., Milani, L., Neville, M., Orho-Melander, M., Qi, L., Qi, Q., Roden, M., Rolandsson, O., Swift, A., Rosengren, A. H., Stirrups, K., Wood, A. R., Mihailov, E., Blancher, C., Carneiro, M. O., Maguire, J., Poplin, R., Shakir, K., Fennell, T., DePristo, M., De Angelis, M. H., Deloukas, P., Gjesing, A. P., Jun, G., Nilsson, P. M., Murphy, J., Onofrio, R., Thorand, B., Hansen, T., Meisinger, C., Hu, F. B., Isomaa, B., Karpe, F., Liang, L., Peters, A., Huth, C., O'Rahilly, S. P., Palmer, C. N. A., Pedersen, O., Rauramaa, R., Tuomilehto, J., Salomaa, V., Watanabe, R. M., Syvänen, A. C., Bergman, R. N., Bharadwaj, D., Bottinger, E. P., Cho, Y. S., Chandak, G. R., Chan, J. C. N., Chia, K. S., Daly, M. J., Ebrahim, S. B., Langenberg, C., Elliott, P., Jablonski, K. A., Lehman, D. M., Jia, W., Ma, R. C. W., Pollin, T. I., Sandhu, M., Tandon, N., Froguel, P., Barroso, I., Teo, Y. Y., Zeggini, E., Loos, R. J. F., Small, K. S., Ried, J. S., DeFronzo, R. A., Grallert, H., Glaser, B., Metspalu, A., Wareham, N. J., Walker, M., Banks, E., Gieger, C., Ingelsson, E., Im, H. K., Illig, T., Franks, P. W., Buck, G., Trakalo, J., Buck, D., Prokopenko, I., Mägi, R., Lind, L., Farjoun, Y., Owen, K. R., Gloyn, A. L., Strauch, K., Tuomi, T., Kooner, J. S., Lee, J. Y., Park, T., Donnelly, P., Morris, A. D., Hattersley, A. T., Bowden, D. W., Collins, F. S., Atzmon, G., Chambers, J. C., Spector, T. D., Laakso, M., Strom, T. M., Bell, G. I., Blangero, J., Duggirala, R., Tai, E., McVean, G., Hanis, C. L., Wilson, J. G., Seielstad, M., Frayling, T. M., Meigs, J. B., Cox, N. J., Sladek, R., Lander, E. S., Gabriel, S., Mohlke, K. L., Meitinger, T., Groop, L., Abecasis, G., Scott, L. J., Morris, A. P., Kang, H. M., Altshuler, D., Burtt, N. P., Florez, J. C., Boehnke, M. & McCarthy, M. I., Dec 19 2017, In: Scientific Data. 4, 170179.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    21 Scopus citations

  • Effect of Exceptional Parental Longevity and Lifestyle Factors on Prevalence of Cardiovascular Disease in Offspring

    Gubbi, S., Schwartz, E., Crandall, J., Verghese, J., Holtzer, R., Atzmon, G., Braunstein, R., Barzilai, N. & Milman, S., Dec 15 2017, In: American Journal of Cardiology. 120, 12, p. 2170-2175 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    20 Scopus citations

  • Erratum. Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol's Effects on Insulin Action in Rats. Diabetes 2011;60:2691-2700

    Knight, C. M., Gutierrez-Juarez, R., Lam, T. K. T., Arrieta-Cruz, I., Huang, L., Schwartz, G., Barzilai, N. & Rossetti, L., Dec 1 2017, In: Diabetes. 66, 12, p. 3143-3144 2 p.

    Research output: Contribution to journal › Comment/debate › peer-review

    Open Access

  • Four Genome-Wide Association Studies Identify New Extreme Longevity Variants

    Sebastiani, P., Gurinovich, A., Bae, H., Andersen, S., Malovini, A., Atzmon, G., Villa, F., Kraja, A. T., Ben-Avraham, D., Barzilai, N., Puca, A. & Perls, T. T., Nov 1 2017, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 72, 11, p. 1453-1464 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    79 Scopus citations