TY - JOUR
T1 - Chronic inflammation in the etiology of disease across the life span
AU - Furman, David
AU - Campisi, Judith
AU - Verdin, Eric
AU - Carrera-Bastos, Pedro
AU - Targ, Sasha
AU - Franceschi, Claudio
AU - Ferrucci, Luigi
AU - Gilroy, Derek W.
AU - Fasano, Alessio
AU - Miller, Gary W.
AU - Miller, Andrew H.
AU - Mantovani, Alberto
AU - Weyand, Cornelia M.
AU - Barzilai, Nir
AU - Goronzy, Jorg J.
AU - Rando, Thomas A.
AU - Effros, Rita B.
AU - Lucia, Alejandro
AU - Kleinstreuer, Nicole
AU - Slavich, George M.
N1 - Publisher Copyright:
© 2019, Springer Nature America, Inc.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.
AB - Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.
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U2 - 10.1038/s41591-019-0675-0
DO - 10.1038/s41591-019-0675-0
M3 - Article
C2 - 31806905
AN - SCOPUS:85076175435
SN - 1078-8956
VL - 25
SP - 1822
EP - 1832
JO - Nature Medicine
JF - Nature Medicine
IS - 12
ER -