Undulating changes in human plasma proteome profiles across the lifespan

Benoit Lehallier; David Gate; Nicholas Schaum; Tibor Nanasi; Song Eun Lee; Hanadie Yousef; Patricia Moran Losada; Daniela Berdnik; Andreas Keller; Joe Verghese; Sanish Sathyan; Claudio Franceschi; Sofiya Milman; Nir Barzilai; Tony Wyss-Coray

doi:10.1038/s41591-019-0673-2

Undulating changes in human plasma proteome profiles across the lifespan

Benoit Lehallier, David Gate, Nicholas Schaum, Tibor Nanasi, Song Eun Lee, Hanadie Yousef, Patricia Moran Losada, Daniela Berdnik, Andreas Keller, Joe Verghese, Sanish Sathyan, Claudio Franceschi, Sofiya Milman, Nir Barzilai, Tony Wyss-Coray

Research output: Contribution to journal › Article › peer-review

377 Scopus citations

Abstract

Aging is a predominant risk factor for several chronic diseases that limit healthspan¹. Mechanisms of aging are thus increasingly recognized as potential therapeutic targets. Blood from young mice reverses aspects of aging and disease across multiple tissues^2–10, which supports a hypothesis that age-related molecular changes in blood could provide new insights into age-related disease biology. We measured 2,925 plasma proteins from 4,263 young adults to nonagenarians (18–95 years old) and developed a new bioinformatics approach that uncovered marked non-linear alterations in the human plasma proteome with age. Waves of changes in the proteome in the fourth, seventh and eighth decades of life reflected distinct biological pathways and revealed differential associations with the genome and proteome of age-related diseases and phenotypic traits. This new approach to the study of aging led to the identification of unexpected signatures and pathways that might offer potential targets for age-related diseases.

Original language	English (US)
Pages (from-to)	1843-1850
Number of pages	8
Journal	Nature Medicine
Volume	25
Issue number	12
DOIs	https://doi.org/10.1038/s41591-019-0673-2
State	Published - Dec 1 2019

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41591-019-0673-2

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title = "Undulating changes in human plasma proteome profiles across the lifespan",

abstract = "Aging is a predominant risk factor for several chronic diseases that limit healthspan1. Mechanisms of aging are thus increasingly recognized as potential therapeutic targets. Blood from young mice reverses aspects of aging and disease across multiple tissues2–10, which supports a hypothesis that age-related molecular changes in blood could provide new insights into age-related disease biology. We measured 2,925 plasma proteins from 4,263 young adults to nonagenarians (18–95 years old) and developed a new bioinformatics approach that uncovered marked non-linear alterations in the human plasma proteome with age. Waves of changes in the proteome in the fourth, seventh and eighth decades of life reflected distinct biological pathways and revealed differential associations with the genome and proteome of age-related diseases and phenotypic traits. This new approach to the study of aging led to the identification of unexpected signatures and pathways that might offer potential targets for age-related diseases.",

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AU - Gate, David

AU - Schaum, Nicholas

AU - Nanasi, Tibor

AU - Lee, Song Eun

AU - Yousef, Hanadie

AU - Moran Losada, Patricia

AU - Berdnik, Daniela

AU - Keller, Andreas

AU - Verghese, Joe

AU - Sathyan, Sanish

AU - Franceschi, Claudio

AU - Milman, Sofiya

AU - Barzilai, Nir

AU - Wyss-Coray, Tony

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Aging is a predominant risk factor for several chronic diseases that limit healthspan1. Mechanisms of aging are thus increasingly recognized as potential therapeutic targets. Blood from young mice reverses aspects of aging and disease across multiple tissues2–10, which supports a hypothesis that age-related molecular changes in blood could provide new insights into age-related disease biology. We measured 2,925 plasma proteins from 4,263 young adults to nonagenarians (18–95 years old) and developed a new bioinformatics approach that uncovered marked non-linear alterations in the human plasma proteome with age. Waves of changes in the proteome in the fourth, seventh and eighth decades of life reflected distinct biological pathways and revealed differential associations with the genome and proteome of age-related diseases and phenotypic traits. This new approach to the study of aging led to the identification of unexpected signatures and pathways that might offer potential targets for age-related diseases.

AB - Aging is a predominant risk factor for several chronic diseases that limit healthspan1. Mechanisms of aging are thus increasingly recognized as potential therapeutic targets. Blood from young mice reverses aspects of aging and disease across multiple tissues2–10, which supports a hypothesis that age-related molecular changes in blood could provide new insights into age-related disease biology. We measured 2,925 plasma proteins from 4,263 young adults to nonagenarians (18–95 years old) and developed a new bioinformatics approach that uncovered marked non-linear alterations in the human plasma proteome with age. Waves of changes in the proteome in the fourth, seventh and eighth decades of life reflected distinct biological pathways and revealed differential associations with the genome and proteome of age-related diseases and phenotypic traits. This new approach to the study of aging led to the identification of unexpected signatures and pathways that might offer potential targets for age-related diseases.

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Undulating changes in human plasma proteome profiles across the lifespan

Abstract

ASJC Scopus subject areas

UN SDGs

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