Transition states of native and drug-resistant HIV-1 protease are the same

Pharmacology, Toxicology and Pharmaceutical Science

• Human Immunodeficiency Virus Proteinase 100%
• Carboxamide 50%
• Carbon 14 50%
• Drug Resistance 50%
• Nitrogen 15 50%
• Oxygen 18 50%
• HIV 25%
• Hydrogen Bond 25%
• Bond Cleavage 25%

Biochemistry, Genetics and Molecular Biology

• Kinetic Isotope Effect 100%
• HIV-1 Protease 100%
• Enzyme 30%
• Proton Transport 20%
• Drug Resistance 20%
• Transition State Analog 10%
• Hydrogen Bond 10%
• Human Immunodeficiency Virus 10%
• Nucleophilicity 10%
• Active Site 10%
• Enzyme Chemistry 10%

Keyphrases

• Transition Structure 20%
• C-N Bond Cleavage 10%
• Bond Loss 10%