Projects per year
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Collaborations and top research areas from the last five years
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Targeting Clostridioides difficile with microbiome-sparing, resistant-proof anti-toxins
National Institute of Allergy and Infectious Diseases
4/1/21 → 3/31/24
Project: Research project
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Transition State Analysis of Enzymatic Reactions
Schramm, V. L. & Schramm, V. V. L.
National Institute of General Medical Sciences
8/1/89 → 7/31/24
Project: Research project
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Cancer Center Support Grant
Almo, S. C., Hogue-Angeletti, R., Augenlicht, L. H., Condeelis, J. S., Desai, K. K., Edelmann, W., Goldman, I. D., Greally, J. M., Herbst, L. H., Keller, S. M., Kim, M., Mahmood, R., Montagna, C., Morrow, B. E., Pollard, J. W., Porcelli, S. A., Rohan, T. E., Scharff, M. D., Seither, R., Skoultchi, A. I., Sparano, J. A., Stanley, P. M., Chu, E. E., Bresnick, A. R., Skoultchi, A. A. I., Adedimeji, A. A., Beck, A. A. P., Blanchard, J. S., Halmos, B. B., Morrow, B. B., Diamond, B. B., Rapkin, B. D., Chu, E., Montagna, C. C., Stein, D. T., Gaertner, D. D. J., Chu, E. E., Ho, G. G. Y., Goel, S., Hosgood, H. D. H., Strickler, H. H. D., Goldman, I. I. D., Pollard, J. J. W., Condeelis, J. J. S., Dutcher, J. J. P., Greally, J. M., Backer, J. M., Sparano, J., Aguirre-ghiso, J. J. A., Desai, K. K., Gritsman, K., Herbst, L. H., Augenlicht, L. H., Cannizzaro, L. A., Hackett, L. L. E., Scharff, M. M. D., Brenowitz, M. D., Kim, M. M. Y., Ohri, N. N., Stanley, P., Mahmood, R. R., Gupta, R. R. K., Seither, R. R. L., Depinho, R. R. A., Angeletti, R. R. H., Kucherlapati, R. R. S., Schramm, V. L., Keller, S. M., Almo, S. E., Porcelli, S. A., Rohan, T. E., Steidl, U. U. G., Rapkin, B. B. D., Xue, X. N., Alderman, M. H., Atkinson, P. H., Bases, R. E., Birshstein, B. K., Bloom, B. R., Blumenfeld, O. O., Brenowitz, M. D., Brewer, F. C., Buhl, S., Cannizzaro, L. A., Chance, M. R., Chase, J. W., Childs, G. J., Depinho, R., Depinho, R. A., Diamond, B. A., Diamond, B., Duran-reynals, M. L., Dutcher, J. P., Eagle, H., Fant, J., Gaertner, D. J., Grills, G., Gupta, R. K., Ho, G. Y., Band Horwitz, S., Horwitz, M. S., Hurwitz, J., Kadish, A. S., Klinger, H. P., Krauter, K. S., Kucherlapati, R. S., Levine, W. G., Lilly, F., Maio, J. J., Maitra, U., Makman, M. H., Marians, K. J., Nathenson, S. G., Orr, G. A., Peisach, J., Pickering, K., Rajan, T. V., Reid, L. M., Rubin, C. S., Russel, R., Satir, B. H., Schildkraut, C. L., Schulman, L. H., Serrano, L. J., Shapiro, L., Shin, S., Wadler, S. H., Warner, J. R., West, M. & Wiernik, P. H.
6/1/85 → 6/30/24
Project: Research project
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PROTOZOAN PURINE PHOSPHORIBOSYLTRANSFERASES AS TARGETS TO TREAT MALARIA, AFRICAN TRYPANOSOMIASIS AND CHAGAS'S DISEASE
Schramm, V. L. & Schramm, V. L.
9/25/17 → 8/31/21
Project: Research project
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An enzyme-coupled microplate assay for activity and inhibition of hmdUMP hydrolysis by DNPH1
Wagner, A. G., Eskandari, R. & Schramm, V. L., Jul 1 2023, In: Analytical Biochemistry. 672, 115171.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
MAT Gain of Activity Mutation in Helicobacter pylori Is Associated with Resistance to MTAN Transition State Analogues
Feng, M., Namanja-Magliano, H., Rajagopalan, S., Mishra, T., Ducati, R. G., Hirsch, B. M., Kelly, L., Szymczak, W., Fajardo, J. E., Sidoli, S., Fiser, A., Jacobs, W. R. & Schramm, V. L., Apr 14 2023, In: ACS Infectious Diseases. 9, 4, p. 966-978 13 p.Research output: Contribution to journal › Article › peer-review
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Phosphoinositide and redox dysregulation by the anticancer methylthioadenosine phosphorylase transition state inhibitor
Salita, T., Rustam, Y. H., Hofferek, V., Jackson, M., Tollestrup, I., Sheridan, J. P., Schramm, V. L., Evans, G. B., Reid, G. E. & Munkacsi, A. B., Sep 2023, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1868, 9, 159346.Research output: Contribution to journal › Article › peer-review
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Residence Times for Femtomolar and Picomolar Inhibitors of MTANs
Brown, M., Tyler, P. C. & Schramm, V. L., Jun 6 2023, In: Biochemistry. 62, 11, p. 1776-1785 10 p.Research output: Contribution to journal › Article › peer-review
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Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an SNi Mechanism and Ion Pair Transition State
Paparella, A. S., Cahill, S. M., Aboulache, B. L. & Schramm, V. L., Sep 16 2022, In: ACS Chemical Biology. 17, 9, p. 2507-2518 12 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations