Transition state variation in enzymatic reactions

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Experimental analysis of enzymatic transition states by kinetic isotope effect methods has established geometric variation in related transition state structures. Differences are apparent in development of the reaction coordinate, in solvolytic transition states relative to those in enzymatic catalytic sites, in the stereochemistry of related substrates at the transition state, and in reactions catalyzed by related enzymes.

Original languageEnglish (US)
Pages (from-to)556-564
Number of pages9
JournalCurrent Opinion in Chemical Biology
Issue number5
StatePublished - Oct 1 2001

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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