Transition state analogue inhibitors of N-ribosyltransferases: new drugs by targeting nucleoside processing enzymes.

Gary B. Evans; Richard H. Furneaux; Peter M. Kelly; Vern L. Schramm; Peter C. Tyler

doi:10.1093/nass/nrm032

Transition state analogue inhibitors of N-ribosyltransferases: new drugs by targeting nucleoside processing enzymes.

Gary B. Evans, Richard H. Furneaux, Peter M. Kelly, Vern L. Schramm, Peter C. Tyler

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The characterization of the transition state structure of a number of N-ribosyltransferases has enabled the design and synthesis of some extremely powerful inhibitors of these enzymes. We have three generations of inhibitors for some nucleoside processing enzymes which are therapeutic targets, and the potency of these compounds confers special advantages in their development as new drugs against cancer, autoimmune diseases, microbial infections and malaria.

Original language	English (US)
Pages (from-to)	63-64
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	51
DOIs	https://doi.org/10.1093/nass/nrm032
State	Published - 2007
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/nass/nrm032

Cite this

@article{81097e05cc9f4513bb37e5307f1b174d,

title = "Transition state analogue inhibitors of N-ribosyltransferases: new drugs by targeting nucleoside processing enzymes.",

abstract = "The characterization of the transition state structure of a number of N-ribosyltransferases has enabled the design and synthesis of some extremely powerful inhibitors of these enzymes. We have three generations of inhibitors for some nucleoside processing enzymes which are therapeutic targets, and the potency of these compounds confers special advantages in their development as new drugs against cancer, autoimmune diseases, microbial infections and malaria.",

author = "Evans, {Gary B.} and Furneaux, {Richard H.} and Kelly, {Peter M.} and Schramm, {Vern L.} and Tyler, {Peter C.}",

note = "Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine",

year = "2007",

doi = "10.1093/nass/nrm032",

language = "English (US)",

pages = "63--64",

journal = "Nucleic acids symposium series (2004)",

issn = "1746-8272",

publisher = "Oxford University Press",

number = "51",

}

TY - JOUR

T1 - Transition state analogue inhibitors of N-ribosyltransferases

T2 - new drugs by targeting nucleoside processing enzymes.

AU - Evans, Gary B.

AU - Furneaux, Richard H.

AU - Kelly, Peter M.

AU - Schramm, Vern L.

AU - Tyler, Peter C.

N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

PY - 2007

Y1 - 2007

N2 - The characterization of the transition state structure of a number of N-ribosyltransferases has enabled the design and synthesis of some extremely powerful inhibitors of these enzymes. We have three generations of inhibitors for some nucleoside processing enzymes which are therapeutic targets, and the potency of these compounds confers special advantages in their development as new drugs against cancer, autoimmune diseases, microbial infections and malaria.

AB - The characterization of the transition state structure of a number of N-ribosyltransferases has enabled the design and synthesis of some extremely powerful inhibitors of these enzymes. We have three generations of inhibitors for some nucleoside processing enzymes which are therapeutic targets, and the potency of these compounds confers special advantages in their development as new drugs against cancer, autoimmune diseases, microbial infections and malaria.

UR - http://www.scopus.com/inward/record.url?scp=42949125466&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42949125466&partnerID=8YFLogxK

U2 - 10.1093/nass/nrm032

DO - 10.1093/nass/nrm032

M3 - Article

C2 - 18029587

AN - SCOPUS:42949125466

SN - 1746-8272

SP - 63

EP - 64

JO - Nucleic acids symposium series (2004)

JF - Nucleic acids symposium series (2004)

IS - 51

ER -

Transition state analogue inhibitors of N-ribosyltransferases: new drugs by targeting nucleoside processing enzymes.

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this