Synthesis of 5′-methylthio coformycins: Specific inhibitors for malarial adenosine deaminase

Keyphrases

• Adenosine Deaminase 100%
• Specific Inhibitor 100%
• Methylthiol 100%
• Plasmodium Falciparum 83%
• Purine Salvage 50%
• Transition State Inhibitors 33%
• Transition State 33%
• Dissociation Constant 33%
• Methylthioadenosine 33%
• Deoxycoformycin 33%
• Transition State Analogue 16%
• Substrate Specificity 16%
• Malaria Parasite 16%
• Binding Energy 16%
• Tight-binding 16%
• Catalytic Efficiency 16%
• Adenosine 16%
• Natural Products 16%
• Transition State Stabilization 16%
• Deamination 16%
• Transition State Theory 16%
• Chemically Stable 16%
• Potential for Development 16%
• Transition-state Complex 16%
• Tetrahedral Geometry 16%
• Adenosine Deamination 16%
• Product Transition 16%
• Rate Acceleration 16%
• Essential Pathway 16%
• Stable Analogues 16%
• Adenosine Deaminase Inhibitor 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Adenosine Deaminase 100%
• Coformycin 100%
• Enzymes 66%
• Purine 50%
• Adenosine 33%
• Pentostatin 33%
• Plasmodium falciparum 33%
• Parasite 33%
• Plasmodium 16%
• Natural Product 16%
• Antimalarial Agent 16%
• Substrate Specificity 16%
• Adenosine Deaminase Inhibitor 16%
• Side Effect 16%
• Protozoan 16%
• Cat 16%
• Bovine 16%

Biochemistry, Genetics and Molecular Biology

• Adenosine Deaminase 100%
• Enzyme 57%
• Transition State Analog 28%
• Plasmodium falciparum 28%
• Dissociation Constant 28%
• Pentostatin 28%
• Deamination 28%
• Adenosine 28%
• Parasite 28%
• Enzyme Specificity 14%
• Plasmodium 14%
• Catalytic Efficiency 14%
• Binding Energy 14%
• Protozoan 14%
• Bovine 14%
• Cat 14%