Picomolar Transition State Analogue Inhibitors of Human 5′-Methylthioadenosine Phosphorylase and X-ray Structure with MT-Immucillin-A

Medicine & Life Sciences

• 5'-methylthioadenosine phosphorylase 100%
• immucillin A 83%
• Phosphorylases 80%
• X-Rays 43%
• Polyamines 40%
• pyrrolidine 35%
• Cations 34%
• methylthio-DADMe-immucillin-A 28%
• Anions 24%
• Spermine Synthase 21%
• Spermidine Synthase 20%
• Phosphates 19%
• Ions 18%
• Catalytic Domain 10%
• Mammals 10%
• 1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-methylthioribitol 8%
• methylthio-immucillin-A 1%

Chemical Compounds

• Transition State 46%
• X-Ray 34%
• Dissociation Constant 30%
• Polyamine 26%
• Pyrrolidine 17%
• Spermidine 10%
• Spermine 9%
• Anion 9%
• Cation 9%
• Crystal Structure 8%
• Ion Pair 7%
• Binding Energy 7%
• Kd 6%
• Phosphate 5%
• Substitution Reaction 5%
• Volume 4%
• Ion 3%