Leaving group activation and pyrophosphate ionic state at the catalytic site of plasmodium falciparum orotate phosphoribosyltransferase

Engineering & Materials Science

• Hydrogen bonds 77%
• Chemical activation 50%
• Isotopes 46%
• Nucleophiles 39%
• Fourier transforms 36%
• Polarization 34%
• Infrared radiation 32%
• Ground state 28%
• Peptides 24%
• Spectrometry 24%
• Alkalinity 24%
• Atoms 19%
• Molecules 18%
• Acids 17%
• Water 10%

Medicine & Life Sciences

• Orotate Phosphoribosyltransferase 100%
• orotidylic acid 75%
• diphosphoric acid 75%
• Plasmodium falciparum 59%
• Catalytic Domain 51%
• Hydrogen Bonding 29%
• Fourier Analysis 19%
• Isotopes 17%
• Orotic Acid 12%
• Spectrum Analysis 7%
• Kinetics 5%
• Water 5%
• Peptides 5%

Chemical Compounds

• Orotate 87%
• Orotidine 51%
• Hydrogen Bond 11%
• Transition State 10%
• Polarization 9%
• Orotic Acid 9%
• Fourier Transform Infrared Spectroscopy 7%
• Kinetic Isotope Effect 6%
• Chemical Bond 6%
• Nucleophile 5%
• Ground State 4%
• IR Spectroscopy 4%
• Peptide 3%
• Molecule 2%