Electrophilic aromatic selenylation: New OPRT inhibitors

Mohannad Abdo, Yong Zhang, Vern L. Schramm, Spencer Knapp

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


2-Ethoxyethaneseleninic acid reacts with electron-rich aromatic substrates to deliver, by way of the selenoxides, the (2-ethoxyethyl)seleno ethers, which can in turn be transformed into a diverse set of aryl-selenylated products. Among these, a family of 5-uridinyl derivatives shows submicromolar inhibition of human and malarial orotate phosphoribosyltransferase.

Original languageEnglish (US)
Pages (from-to)2982-2985
Number of pages4
JournalOrganic Letters
Issue number13
StatePublished - Jul 2 2010

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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