Keyphrases
Vulnerability
100%
Genetic Inactivation
100%
Biallelic
100%
Small Cell Lung Cancer
100%
Tumor Protein p53 (TP53)
100%
Cks1
92%
Patient-derived Xenograft
23%
Chemotherapy
15%
Ubiquitination
15%
Lung Cancer Patients
15%
Post-chemotherapy
15%
Downstream Targets
15%
New Drugs
15%
Chemoresistant
15%
Oncogenic Function
15%
Non-small Cell Lung Cancer Cells
15%
Nave
15%
Liver Metastasis
7%
Treatment Strategy
7%
Antitumor Effect
7%
Genetic Features
7%
Non-small Cell Lung Cancer (NSCLC)
7%
Pro-apoptotic
7%
Cisplatin
7%
Same Patient
7%
Tumor Suppressor
7%
Active Small Molecules
7%
Lung-other
7%
Synthetic Lethal
7%
Drug-resistant Tumor
7%
First-line Therapy
7%
Initial Treatment
7%
Clinical Relapse
7%
Early Metastasis
7%
Molecular Targets
7%
Isogenic
7%
Clinically Significant
7%
Biallelic mutations
7%
Drug Use
7%
% Response
7%
Missense mutation
7%
Etoposide
7%
Pharmacologic
7%
Phase II Trial
7%
CDKN1B
7%
E3 Ubiquitin Ligase
7%
Cell Cycle Regulation
7%
Effective Compounds
7%
Small Molecules
7%
Tumor
7%
Specific Intent
7%
Solid Tumors
7%
Apoptosis
7%
In Vivo Model
7%
5-year Survival
7%
TP53 Deletion
7%
Mouse Tumor Model
7%
Chemosensitive
7%
Cancer Tumor
7%
Aggressive Growth
7%
Targeted Drugs
7%
Pro-tumorigenic
7%
Medicine and Dentistry
Small Cell Lung Cancer
100%
Protein P53
25%
Chemotherapy
25%
Xenograft
18%
Neoplasm
18%
Cancer Cell
12%
Ubiquitination
12%
Programmed Cell Death
6%
Tumor Model
6%
Cisplatin
6%
Ubiquitin Protein Ligase E3
6%
In Vitro
6%
Liver Metastasis
6%
Solid Malignant Neoplasm
6%
Non Small Cell Lung Cancer
6%
Etoposide
6%
Survival Rate
6%
CDKN1B
6%
Cell Cycle Regulation
6%
Metastatic Carcinoma
6%
Missense Mutation
6%
Tumor Suppressor Protein
6%
Pharmacology, Toxicology and Pharmaceutical Science
Small Cell Lung Cancer
100%
Protein P53
25%
Chemotherapy
25%
Neoplasm
18%
Molecular Target
6%
Ubiquitin Protein Ligase E3
6%
Etoposide
6%
Survival Rate
6%
Cyclin Dependent Kinase Inhibitor 1B
6%
Liver Metastasis
6%
Tumor Model
6%
Non Small Cell Lung Cancer
6%
Cisplatin
6%
Solid Malignant Neoplasm
6%
Tumor Suppressor Protein
6%