Developmental & Molecular Biology

Projects

Projects per year 1979 2005 2009 2010 2014 2016 2019 2025

• 8 Active
• 139 Finished

Projects per year

Search results

• Finished

  Modernization of Zebrafish Core Facility

  Bowman, T. V.

  8/1/22 → 7/31/23

  Project: Research project

  • Danio rerio 100%
  • modernization 25%
  • dissolved gases 17%
  • neoplasms 16%
  • drug design 16%

• Identification of novel regulators of HSC specification and maturation

  Bowman, T. V.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/23/21 → 6/30/22

  Project: Research project

  • Hematopoietic Stem Cells 100%
  • Zebrafish 26%
  • Cell Self Renewal 16%
  • Transplantation 14%
  • Induced Pluripotent Stem Cells 14%

• Microglia-Neuron Interactions: Roles for Microglial Iba1

  Castillo, P. E. & Nandi, S.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  12/1/20 → 10/31/23

  Project: Research project

  • Microglia 100%
  • Neurons 47%
  • Brain 22%
  • Proteins 19%
  • Macrophages 19%

• Einstein's Nathan Shock Center of Excellence in Basic Biology of Aging

  Cuervo, A. M. & Cuervo, A. A. M.

  National Institute on Aging

  9/15/20 → 5/31/23

  Project: Research project

  • Proteostasis 100%
  • Shock 48%
  • Drug Design 11%
  • Research Design 9%
  • Research Personnel 6%

• AIF1/Iba1 in microglial function and stroke

  Sibinga, N. E. S. & Nandi, S.

  National Institute of Neurological Disorders and Stroke

  7/1/20 → 6/30/22

  Project: Research project

  • Stroke 100%
  • Microglia 94%
  • Wounds and Injuries 44%
  • Inflammation Mediators 19%
  • Cell Lineage 16%

• Proj 1 - Interplay between peripheral autophagy and AD in aging

  Cuervo, A. M. & Cuervo, A. M.

  National Institute on Aging

  4/1/20 → 3/31/24

  Project: Research project

  • Autophagy 100%
  • Proteostasis 72%
  • Brain 18%
  • Dementia 15%
  • Biostatistics 14%

• Core A - AdministrativeCore/Biocomputational Unit

  Cuervo, A. M. & Cuervo, A. M.

  National Institute on Aging

  4/1/20 → 3/31/24

  Project: Research project

  • biostatistics 100%
  • advisory committees 58%
  • data analysis 52%
  • statistical analysis 32%
  • experimental design 30%

• Crosstalk of Splicing and Signaling during HSC Formation

  Bowman, T. V.

  9/1/19 → 6/30/22

  Project: Research project

  • Hematopoietic Stem Cells 100%
  • RNA Splicing 49%
  • RNA Splicing Factors 36%
  • Hemangioblasts 29%
  • Protein Isoforms 22%

• Crosstalk of Splicing and Signaling during HSC Formation

  Bowman, T. V.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/1/19 → 8/31/20

  Project: Research project

  • Hematopoietic Stem Cells 100%
  • RNA Splicing 51%
  • RNA Splicing Factors 38%
  • Hemangioblasts 31%
  • Protein Isoforms 23%

• Multidisciplinary Research Training in Gastroenterology and Hepatology

  Cohen, D.

  5/1/19 → 4/30/22

  Project: Research project

  • Interdisciplinary Research 100%
  • Gastroenterology 99%
  • Education 83%
  • Medicine 53%
  • metariboadenosine triphosphorous 32%

• Multidisciplinary Research Training in Gastroenterology and Hepatology

  Longman, R. & Cohen, D.

  National Institute of Diabetes and Digestive and Kidney Diseases

  5/1/19 → 4/30/24

  Project: Research project

  • Interdisciplinary Research 100%
  • Gastroenterology 86%
  • Education 42%
  • Medicine 34%
  • metariboadenosine triphosphorous 21%

• Vulnerability of SCLC based on bi-allelic genetic inactivation of RB1 and TP53

  Zhao, H. & Schwartz, E. L.

  4/12/19 → 3/31/22

  Project: Research project

  • Small Cell Lung Carcinoma 100%
  • Drug Therapy 17%
  • Heterografts 16%
  • Ubiquitination 13%
  • Neoplasms 11%

• Vulnerability of SCLC based on bi-allelic genetic inactivation of RB1 and TP53

  Schwartz, E. L. & Zhao, H.

  National Cancer Institute

  4/12/19 → 3/31/24

  Project: Research project

  • Small Cell Lung Carcinoma 100%
  • Heterografts 18%
  • Drug Therapy 18%
  • Ubiquitination 14%
  • Neoplasms 11%

• Cell-cell adhesion-mediated signaling determines epithelial polarization in the liver

  Muesch, A.

  4/4/19 → 3/31/22

  Project: Research project

  • hepatocytes 100%
  • bile ducts 78%
  • bile 65%
  • cells 59%
  • liver 51%

• Integration of RhoGTPase signaling during cell migration

  Hodgson, L. & Cox, D.

  National Institute of General Medical Sciences

  9/1/18 → 8/31/20

  Project: Research project

  • rho GTP-Binding Proteins 100%
  • Cell Movement 40%
  • Macrophage Colony-Stimulating Factor 38%
  • GTP Phosphohydrolases 27%
  • Macrophages 26%

• Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis

  Cuervo, A. M. & Gavathiotis, E.

  8/9/17 → 5/31/22

  Project: Research project

  • Chaperone-Mediated Autophagy 100%
  • Cystinosis 92%
  • Cystine 33%
  • Cysteamine 12%
  • Kidney 6%

• Neurotropic herpesvirus envelopment and microtubule-mediated transport

  Wilson, D. W.

  3/15/17 → 2/28/22

  Project: Research project

  • Capsid 100%
  • Suid Herpesvirus 1 96%
  • Microtubules 84%
  • Human Herpesvirus 1 76%
  • Virion 66%

• Neurotropic herpesvirus envelopment and microtubule-mediated transport

  Wilson, D. W. & Smith, G. A.

  National Institute of Allergy and Infectious Diseases

  3/15/17 → 11/30/23

  Project: Research project

  • Suid Herpesvirus 1 100%
  • Capsid 97%
  • Herpesviridae 90%
  • Microtubules 82%
  • Human Herpesvirus 1 81%

• Endosomal Microautophagy in Drosophila

  Jenny, A.

  2/1/17 → 1/31/21

  Project: Research project

  • Microautophagy 100%
  • Starvation 24%
  • Autophagy 21%
  • Chaperone-Mediated Autophagy 18%
  • Organelles 16%

• Linking tau proteostasis with neuronal activity in FTD

  Coppola, G., Cuervo, A. M., Gan, L., Grinberg, L. T., Kampmann, M., Kosik, K. S., Krogan, N. J. & Gan, L.

  9/30/16 → 8/31/21

  Project: Research project

  • Proteostasis 100%
  • Clustered Regularly Interspaced Short Palindromic Repeats 58%
  • Frontotemporal Lobar Degeneration 17%
  • Tauopathies 17%
  • Neurons 15%

• Core B: Human Biology Validation Core

  Cuervo, A. M.

  9/1/16 → 8/31/21

  Project: Research project

  • Neurodegenerative diseases 100%
  • Genetics 89%
  • Fluids 85%
  • Pathology 75%
  • Tissue 56%

• Project 3: Autophagy dysfunction and neuronal activity in FTD

  Cuervo, A. M.

  National Institute of Neurological Disorders and Stroke

  9/1/16 → 8/31/21

  Project: Research project

  • Frontotemporal Dementia 100%
  • Autophagy 77%
  • Clustered Regularly Interspaced Short Palindromic Repeats 35%
  • Proteostasis 20%
  • tau Proteins 19%

• Understanding Alzheimer's Disease in the Context of the Aging Brain

  Cuervo, A. M.

  National Institute on Aging

  8/15/16 → 6/30/21

  Project: Research project

  • Chaperone-Mediated Autophagy 100%
  • Proteostasis 34%
  • Alzheimer Disease 33%
  • Brain 30%
  • Genetic Enhancement 12%

• Understanding Alzheimer's Disease in the Context of the Aging Brain

  Cuervo, A. M.

  8/15/16 → 6/30/21

  Project: Research project

  • Chaperone-Mediated Autophagy 100%
  • Proteostasis 34%
  • Brain 32%
  • Genetic Enhancement 12%
  • Homeostasis 9%

• pRb Function in Mediobasal Hypothalamus in Diet Induced Obesity

  Chua, Jr., S. C. & Zhu, L.

  National Institute of Diabetes and Digestive and Kidney Diseases

  7/10/16 → 6/30/21

  Project: Research project

  • Hypothalamus 100%
  • Obesity 77%
  • Diet 74%
  • Leptin 49%
  • Neurons 36%

• Einstein's Nathan Shock Center of Excellence in Basic Biology of Aging

  Cuervo, A. M.

  National Institute on Aging

  7/1/16 → 6/30/19

  Project: Research project

  • technicians 100%
  • Biological Sciences 82%
  • homeostasis 46%
  • assays 42%
  • advisory committees 41%

• Dissecting Skp2 functions in pRb and p53 doubly deficient tumorigenesis

  Schwartz, E. L., Zhao, H. & Zhu, L.

  National Cancer Institute

  6/3/16 → 5/31/21

  Project: Research project

  • prostatic neoplasms 100%
  • carcinogenesis 84%
  • neoplasms 63%
  • castration 61%
  • mice 31%

• WNK KINASES IN DEVELOPMENT

  Jenny, A.

  5/4/16 → 9/30/20

  Project: Research project

  • Phosphotransferases 100%
  • Catenins 54%
  • Gordon syndrome 40%
  • Pseudohypoaldosteronism 35%
  • Sodium-Potassium-Chloride Symporters 34%

• WNK KINASES IN DEVELOPMENT

  Jenny, A.

  National Institute of General Medical Sciences

  5/4/16 → 9/30/20

  Project: Research project

  • Phosphotransferases 100%
  • Catenins 63%
  • Gordon syndrome 47%
  • Pseudohypoaldosteronism 40%
  • Sodium-Potassium-Chloride Symporters 40%

• Autophagic Dysfunction and the Stress Response in Aging (Project 1)

  Cuervo, A. M.

  National Institute on Aging

  5/1/16 → 4/30/18

  Project: Research project

  • Autophagy 100%
  • Chaperone-Mediated Autophagy 76%
  • Macroautophagy 32%
  • Microautophagy 20%
  • Genetic Engineering 14%

• Administrative Core (Core A)

  Cuervo, A. M.

  National Institute on Aging

  5/1/16 → 4/30/18

  Project: Research project

  • advisory committees 100%
  • committees 46%
  • materials handling 29%
  • human resources 20%
  • cells 6%

• Analysis of a mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia.

  Stanley, E. R.

  National Institutes of Health

  9/15/15 → 6/30/20

  Project: Research project

  • Leukoencephalopathies 100%
  • Neuroglia 91%
  • Microglia 18%
  • Hereditary Diffuse Leukoencephalopathy with Spheroids 17%
  • Neurodegenerative Diseases 15%

• Einstein's Nathan Shock Center of Excellence in Basic Biology of Aging

  Cuervo, A. M.

  National Institute on Aging

  7/15/15 → 6/30/16

  Project: Research project

  • technicians 100%
  • Biological Sciences 77%
  • homeostasis 46%
  • assays 42%
  • advisory committees 41%

• Them1-Mediated Metabolic Regulation and Pathogenic Role in NAFLD

  Cohen, D.

  7/5/15 → 5/31/20

  Project: Research project

  • fatty liver 100%
  • brown adipose tissue 35%
  • lipids 32%
  • inflammation 27%
  • endoplasmic reticulum stress 26%

• Interplay of chaperone-mediated autophagy with lipid metabolism and ER stress

  Madrigal Matute, J.

  1/1/15 → 12/31/17

  Project: Research project

  • autophagy 100%
  • metabolic diseases 57%
  • atherosclerosis 26%
  • diabetes 25%
  • metabolism 21%

• SPORE in Thyroid Cancer

  Di Cristofano, A., Seshan, V., Chan, T. A., Ghossein, R., Berger, M. & Fagin, J.

  9/19/14 → 8/31/20

  Project: Research project

  • Thyroid Neoplasms 100%
  • Translational Medical Research 37%
  • Biostatistics 24%
  • Oxyphil Cells 24%
  • Anaplastic Thyroid Carcinoma 23%

• SPORE in Thyroid Cancer

  Fagin, J. A., Berger, M., Chan, T. A., Di Cristofano, A., Ghossein, R. A. & Seshan, V. E.

  9/19/14 → 8/31/20

  Project: Research project

  • Thyroid Neoplasms 100%
  • Translational Medical Research 37%
  • Biostatistics 24%
  • Oxyphil Cells 24%
  • Anaplastic Thyroid Carcinoma 23%

• GENETICALLY MODIFIED HEPATOCYTES TO ACHIEVE SUCCESS IN LIVER CELL TRANSPLANTATION

  Zhu, L., Shafritz, D. & Zhu, L.

  9/15/14 → 7/31/20

  Project: Research project

  • Yap 100%
  • hepatocytes 60%
  • liver 34%
  • stem cells 27%
  • tamoxifen 18%

• GENETICALLY MODIFIED HEPATOCYTES TO ACHIEVE SUCCESS IN LIVER CELL TRANSPLANTATION

  Shafritz, D. A. & Zhu, L.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/15/14 → 7/31/15

  Project: Research project

  • Yap 100%
  • cell transplantation 74%
  • hepatocytes 53%
  • liver 34%
  • stem cells 27%

• Administrative Core (Core A)

  Cuervo, A. M.

  National Institute on Aging

  9/15/14 → 4/30/16

  Project: Research project

  • advisory committees 100%
  • committees 46%
  • materials handling 29%
  • human resources 20%
  • cells 6%

• Autophagic Dysfunction and the Stress Response in Aging (Project 1)

  Cuervo, A. M.

  National Institute on Aging

  9/15/14 → 4/30/16

  Project: Research project

  • Autophagy 100%
  • Chaperone-Mediated Autophagy 76%
  • Macroautophagy 32%
  • Microautophagy 20%
  • Genetic Engineering 14%

• Splicing and Epigenetics Regulation of Hematopoietic Stem Cells

  Bowman, T. V.

  9/4/14 → 8/31/16

  Project: Research project

  • Hematopoietic Stem Cells 100%
  • Epigenomics 16%
  • Wnt Signaling Pathway 16%
  • Zebrafish 14%
  • Genomics 9%

• Splicing and Epigenetics Regulation of Hematopoietic Stem Cells

  Bowman, T. V.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/4/14 → 8/31/16

  Project: Research project

  • Hematopoietic Stem Cells 100%
  • Epigenomics 64%
  • Wnt Signaling Pathway 16%
  • Zebrafish 15%
  • Genomics 10%

• Functional assessment of Chaperone Mediated Autophagy during aging in Drosophila

  Jenny, A.

  9/1/14 → 5/31/17

  Project: Research project

  • autophagy 100%
  • Drosophila 16%
  • mice 7%
  • cytoplasm 7%
  • organisms 5%

• Functional assessment of Chaperone Mediated Autophagy during aging in Drosophila

  Jenny, A.

  National Institute on Aging

  9/1/14 → 5/31/17

  Project: Research project

  • autophagy 100%
  • Drosophila 58%
  • mice 7%
  • cytoplasm 7%
  • organisms 5%

• Control of vesicular trafficking in the hepatocyte.

  Cuervo, A. M., Wolkoff, A. W., Rose, S. A., Rose, S. A. & Wolkoff, A. W.

  4/1/13 → 3/31/22

  Project: Research project

  • Endocytosis 100%
  • Autophagy 95%
  • Liver 59%
  • Hepatocytes 41%
  • Personnel Selection 24%

• Decreased Protein Degradation in Aging

  Cuervo, A. M.

  National Institute on Aging

  4/1/13 → 3/31/23

  Project: Research project

  • Chaperone-Mediated Autophagy 100%
  • Proteolysis 53%
  • Homeostasis 9%
  • Quality Control 9%
  • Maintenance 6%

• Control of vesicular trafficking in the hepatocyte

  Wolkoff, A. A. W., Cuervo, A. M. & Wolkoff, A. W.

  National Institute of Diabetes and Digestive and Kidney Diseases

  4/1/13 → 3/31/24

  Project: Research project

  • autophagy 100%
  • Endocytosis 87%
  • Hepatocytes 84%
  • Autophagy 83%
  • fatty liver 77%

• PI3K-mediated metabolic alterations in the pre-neoplastic thyroid

  Di Cristofano, A., Rose, S. A. & Rose, S. A.

  1/1/13 → 12/31/17

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • Oxidative Phosphorylation 56%
  • Glycolysis 53%
  • Tricarboxylic Acids 43%
  • Thyroid Gland 41%

• PI3K-mediated metabolic alterations in the pre-neoplastic thyroid

  Di Cristofano, A.

  National Cancer Institute

  1/1/13 → 12/31/17

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • Thyroid Gland 78%
  • Oxidative Phosphorylation 46%
  • Glycolysis 43%
  • Tricarboxylic Acids 35%