Anatomy & Structural Biology

Projects

Projects per year 1977 1989 1994 2000 2006 2007 2008 2009 2012 2014 2015 2016 2017 2018 2020 2024

• 4 Active
• 117 Finished

Projects per year

Search results

• Active

  Core B - Advance Imaging Core

  Bravo Cordero, J. J., Bravo Cordero, J. J. J. & Santambrogio, L.

  National Institute on Aging

  4/1/20 → 3/31/24

  Project: Research project

  • Microscopy 100%
  • Autophagy 86%
  • Proteostasis 39%
  • Electron Microscopy 38%
  • Intravital Microscopy 36%

• Autophagy in aging: testing geroscience in Alzheimer's disease

  Cuervo, A. A. M., Bravo Cordero, J. J., Gavathiotis, E., Macian-Juan, F., Santambrogio, L., Singh, R. & Cuervo, A. M.

  National Institute on Aging

  2/15/09 → 3/31/24

  Project: Research project

  • Autophagy 100%
  • autophagy 61%
  • Proteostasis 33%
  • Alzheimer Disease 29%
  • Antigen Presentation 26%

• CHARACTERIZATION OF MEMORY-DEPENDENT NIGROTECTAL NEURONS

  Ma, T. P.

  1/6/87 → …

  Project: Research project

• Cancer Center Support Grant

  Almo, S. C., Hogue-Angeletti, R., Augenlicht, L. H., Condeelis, J. S., Desai, K., Edelmann, W., Goldman, I. D., Greally, J. M., Herbst, L. H., Keller, S. M., Kim, M. Y., Mahmood, R., Montagna, C., Morrow, B. E., Pollard, J. W., Porcelli, S. A., Rohan, T. E., Scharff, M. D., Seither, R., Skoultchi, A. I., Sparano, J. A., Stanley, P. M., Chu, E. E., Bresnick, A. R., Skoultchi, A. I., Adedimeji, A. A., Beck, A. P., Blanchard, J. S., Halmos, B. B., Morrow, B. B., Diamond, B. B., Rapkin, B. D., Chu, E., Montagna, C. C., Stein, D. T., Gaertner, D. D. J., Chu, E., Ho, G. Y. F., Goel, S., Hosgood, H. D. H., Strickler, H. H. D., Pollard, J. J. W., Condeelis, J. S., Dutcher, J. P., Greally, J. J., Backer, J. M., Sparano, J., Aguirre-ghiso, J. J. A., Gritsman, K., Herbst, L. H., Augenlicht, L. H., Cannizzaro, L. A., Hackett, L. L. E., Scharff, M. D., Brenowitz, M. D., Kim, M. M. Y., Ohri, N. N., Stanley, P., Gupta, R. R. K., Seither, R. R. L., Depinho, R. R. A., Kucherlapati, R. R. S., Schramm, V. L., Keller, S. M., Almo, S. S., Porcelli, S. A., Rohan, T. E., Steidl, U. U. G., Edelmann, W., Xue, X. N., Alderman, M. H., Atkinson, P. H., Bases, R. E., Birshstein, B. K., Bloom, B. R., Blumenfeld, O. O., Brenowitz, M. D., Brewer, F. C., Buhl, S., Chance, M. R., Chase, J. W., Childs, G. J., Depinho, R., Depinho, R. A., Duran-reynals, M. L., Dutcher, J. P., Eagle, H., Fant, J., Gaertner, D. J., Grills, G., Gupta, R. K., Ho, G. Y., Band Horwitz, S., Horwitz, M. S., Hurwitz, J., Kadish, A. S., Klinger, H. P., Krauter, K. S., Kucherlapati, R. S., Levine, W. G., Lilly, F., Maio, J. J., Maitra, U., Makman, M. H., Marians, K. J., Nathenson, S. G., Orr, G. A., Peisach, J., Pickering, K., Rajan, T. V., Reid, L. M., Rubin, C. S., Russel, R., Satir, B. H., Schildkraut, C. L., Schulman, L. H., Serrano, L. J., Shapiro, L., Shin, S., Wadler, S. H., Warner, J. R., West, M. & Wiernik, P. H.

  National Cancer Institute

  6/1/85 → 6/30/24

  Project: Research project

  • neoplasms 100%
  • species recruitment 38%
  • epidemiology 36%
  • funding 33%
  • gene targeting 26%
• Finished

  The Biology of Lung Metastasis in Breast Cancer

  Backer, J. M., Bresnick, A. A. R., Entenberg, D. R., Oktay, M. H., Porcelli, S. A. & Guo, W.

  7/5/22 → 6/30/23

  Project: Research project

  • Lung 100%
  • Breast Neoplasms 99%
  • Epithelial-Mesenchymal Transition 96%
  • Neoplasm Metastasis 96%
  • Stromal Cells 62%

• Advanced Imaging Core

  Entenberg, D. R.

  6/1/22 → 5/31/23

  Project: Research project

  • Intravital Microscopy 100%
  • Microscopy 51%
  • Lung 33%
  • Psychological Handling 25%
  • Neoplasm Metastasis 25%

• THE EFFECT OF TUMOR MICROENVIRONMENT ON METASTASIS

  Condeelis, J. S., Entenberg, D. R. & Oktay, M. H.

  3/1/21 → 2/28/22

  Project: Research project

  • Neoplasm Metastasis 100%
  • Tumor Microenvironment 91%
  • Neoplasms 85%
  • Breast Neoplasms 46%
  • Drug Therapy 43%

• Following mRNA from birth to death at single-molecule resolution

  Singer, R. H.

  9/17/20 → 8/31/21

  Project: Research project

  • Messenger RNA 100%
  • Photobleaching 56%
  • Cytoplasm 31%
  • Parturition 27%
  • Organized Financing 22%

• Multiplex Imaging of Signaling Pathways in Cell Motility

  Hodgson, L.

  8/1/20 → 7/31/21

  Project: Research project

  • Biosensing Techniques 100%
  • Energy Transfer 76%
  • rho GTP-Binding Proteins 58%
  • GTP Phosphohydrolases 53%
  • Cell Movement 48%

• TMEM, MENAcalc, and MENAINV as Prognostic and Predictive Markers for Breast Cancer Metastasis

  Condeelis, J. S. & Rohan, T. E.

  7/1/20 → 6/30/22

  Project: Research project

  • Breast Neoplasms 100%
  • Neoplasm Metastasis 60%
  • Neoplasms 50%
  • Carcinoma 38%
  • Recurrence 33%

• Head-mounted Photoacoustic Imaging of Deep-brain Neural Activities in Freely Behaving Animals

  Verkhusha, V.

  5/1/20 → 4/30/23

  Project: Research project

  • image analysis 100%
  • brain 84%
  • animals 75%
  • electrodes 57%
  • electric potential difference 55%

• Role of the Kinesin KIF1A in Neurological Disease

  Gennerich, A.

  2/15/20 → 12/31/21

  Project: Research project

  • Kinesin 100%
  • Mutation 87%
  • Brain-Derived Neurotrophic Factor 82%
  • Biophysics 53%
  • Optic Atrophy 51%

• Prometastatic Effects of Neoadjuvant Chemotherapy in Breast Cancer

  Karagiannis, G.

  9/16/19 → 8/31/21

  Project: Research project

  • Neoplasm Metastasis 100%
  • Neoplasms 91%
  • Macrophages 85%
  • Tumor Microenvironment 84%
  • Adjuvant Chemotherapy 82%

• A system for whole-brain recording and control of activated neurons with near-infrared light

  Shcherbakova, D.

  9/1/19 → 8/31/21

  Project: Research project

  • Light 100%
  • Neurons 87%
  • Brain 62%
  • Technology 55%
  • Optogenetics 36%

• New Biosensor Tools for Diaphanous Related Formin MD1A and 2, Useful for Multiplex Imaging

  Hodgson, L.

  7/1/19 → 3/31/21

  Project: Research project

  • Formins 100%
  • rho GTP-Binding Proteins 62%
  • Biosensing Techniques 60%
  • Energy Transfer 43%
  • Wiskott-Aldrich Syndrome Protein Family 28%

• Integration of RhoGTPase signaling during macrophage migration

  Cox, D., Hodgson, L. & Hodgson, L.

  9/1/18 → 8/31/20

  Project: Research project

  • rho GTP-Binding Proteins 100%
  • Macrophage Colony-Stimulating Factor 38%
  • GTP Phosphohydrolases 27%
  • Macrophages 22%
  • Biosensing Techniques 19%

• Timing Endometrial Receptivity

  Meier, U. T.

  8/30/18 → 7/31/20

  Project: Research project

  • embryo transfer 100%
  • embryo implantation 78%
  • endometrium 67%
  • in vitro fertilization 64%
  • assisted reproductive technologies 36%

• Bronx-Einstein Training in Teaching and Research (BETTR), an IRACDA program

  Jones, L., Birshtein, B. K. & Cox, D.

  8/1/18 → 12/31/18

  Project: Research project

  • Teaching 100%
  • experience 40%
  • research project 38%
  • expertise 38%
  • minority 35%

• Tools For Imaging the Functional Genome in Living Cells and Tissues

  Singer, R. H. & Singer, R. H.

  7/1/18 → 6/30/20

  Project: Research project

  • microscopes 100%
  • image analysis 57%
  • phototoxicity 16%
  • modifiers (genes) 14%
  • genome 12%

• Dissecting the dynamic interplay between p53, chromatin and transcriptional bursting in single cells

  Coleman, R. A.

  4/1/18 → 3/31/22

  Project: Research project

  • Chromatin 100%
  • DNA Polymerase II 89%
  • Histones 79%
  • Histone Acetyltransferases 75%
  • Transcription Factors 63%

• Cellular impact of X-linked dyskeratosis congenita

  Meier, U. T.

  9/1/17 → 5/31/21

  Project: Research project

  • NAP57 100%
  • Dyskeratosis Congenita 56%
  • Ribonucleoproteins 16%
  • telomerase RNA 12%
  • RNA 9%

• Preventing neurodegeneration by boosting molecular chaperone expression

  Singer, R. H. & Vera Ugalde, M.

  National Institute on Aging

  8/15/17 → 4/30/20

  Project: Research project

  • Molecular Chaperones 100%
  • Protein Isoforms 71%
  • Protein Aggregates 56%
  • Protein Unfolding 40%
  • Neurons 36%

• Preventing neurodegeneration by boosting molecular chaperone expression

  Singer, R. H.

  8/15/17 → 4/30/20

  Project: Research project

  • Molecular Chaperones 100%
  • Protein Isoforms 98%
  • Protein Aggregates 77%
  • Protein Unfolding 55%
  • Neurons 50%

• Calcium biosensors for deep-tissue imaging and spectral multiplexing

  Verkhusha, V.

  8/1/17 → 7/31/21

  Project: Research project

  • Calcium 100%
  • Phytochrome 35%
  • Proteins 30%
  • Opsins 29%
  • Optogenetics 27%

• 2017 Phagocytes Gordon Research Conference and Gordon Research Seminar

  Cox, D.

  5/8/17 → 5/7/18

  Project: Research project

  • Phagocytes 100%
  • Research Personnel 24%
  • Yin-Yang 12%
  • Students 12%
  • Bioengineering 11%

• Near-Infrared Fluorescent Proteins, Biosensors and Optogenetic Tools

  Verkhusha, V.

  5/1/17 → 4/30/22

  Project: Research project

  • Probe 100%
  • Photochemical Reaction 75%
  • Protein 67%
  • Biliverdin 58%
  • Melanin 51%

• (7) Novel imaging devices for measurement and control of tumor microenvironments

  Entenberg, D. R., Condeelis, J. S., Condeelis, J. S. & Entenberg, D. R.

  4/1/17 → 3/31/22

  Project: Research project

  • Tumor Microenvironment 100%
  • Microfluidics 69%
  • Neoplasm Metastasis 47%
  • Intravital Microscopy 46%
  • Technology 37%

• Near Infrared Genetically Encoded Voltage Indicators (NIR-GEVIs) for All-Optical Electrophysiology (AOE)

  Verkhusha, V.

  9/30/16 → 6/30/21

  Project: Research project

  • Opsins 100%
  • Light 83%
  • Optogenetics 61%
  • Coloring Agents 58%
  • Phytochrome 40%

• Core C: Imaging and Cell Structure Core

  Snapp, E. L.

  National Institute of Diabetes and Digestive and Kidney Diseases

  6/1/16 → 5/31/19

  Project: Research project

  • image analysis 100%
  • cell structures 98%
  • fluorescent proteins 49%
  • microscopy 47%
  • liver 46%

• Roles of formins in breast cancer invasion

  Hodgson, L.

  4/6/16 → 3/31/18

  Project: Research project

  • biosensors 100%
  • guanosinetriphosphatase 63%
  • breast neoplasms 63%
  • microfilaments 59%
  • molecular motor proteins 46%

• Tools for Exceptional Overexpression and Structural Stabilization of Membrane Proteins in Mammalian Cells

  Snapp, E. L., Steinmetz, E. J. & Gennerich, A.

  1/1/16 → 12/31/18

  Project: Research project

  • Crystallization 100%
  • Membrane Proteins 68%
  • Recombinant Proteins 54%
  • Technology 54%
  • Proteins 50%

• Tools for Exceptional Overexpression and Structural Stabilization of Membrane Proteins in Mammalian Cells

  Steinmetz, E. J., Gennerich, A. & Snapp, E. L.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  1/1/16 → 12/31/18

  Project: Research project

  • Crystallization 100%
  • Membrane Proteins 91%
  • Recombinant Proteins 54%
  • Technology 54%
  • Proteins 50%

• Tools For Imaging the Functional Genome in Living Cells and Tissues

  Darzacq, X. & Singer, R. H.

  9/30/15 → 6/30/18

  Project: Research project

  • microscopes 100%
  • image analysis 57%
  • phototoxicity 16%
  • modifiers (genes) 14%
  • genome 12%

• Training of Surgeons for Studies of the Tumor Microenvironment

  Libutti, S. K. & Condeelis, J. S.

  9/25/15 → 6/30/22

  Project: Research project

  • trainee 100%
  • surgery 74%
  • career 69%
  • cancer 65%
  • training program 57%

• 2015 Phagocytes Gordon Research Conference & Gordon Research Seminar

  Cox, D.

  4/20/15 → 8/31/15

  Project: Research project

  • phagocytes 100%
  • macrophages 38%
  • Alzheimer disease 26%
  • fibrosis 26%
  • neutrophils 20%

• Chemical tools for studying membrane protein glycosylation

  Ovryn, B. & Wu, P.

  National Institutes of Health

  4/15/15 → 3/31/19

  Project: Research project

  • Glycosylation 100%
  • Membrane Proteins 73%
  • Polysaccharides 60%
  • Glycoproteins 37%
  • Neoplasms 28%

• Chemical tools for studying membrane protein glycosylation

  Ovryn, B., Wu, P., Wu, P. & Ovryn, B.

  National Institute of General Medical Sciences

  4/15/15 → 3/31/19

  Project: Research project

  • Glycosylation 100%
  • Polysaccharides 64%
  • Membrane Proteins 61%
  • Glycoproteins 39%
  • Neoplasms 29%

• High-speed/resolution whole slide scanner supported by two core facilities

  Condeelis, J. S.

  2/3/15 → 8/31/15

  Project: Research project

  • scanners 100%
  • histology 81%
  • image analysis 67%
  • neoplasms 62%
  • medicine 48%

• The role of KIF9 in glioma invasion

  Segall, J. E.

  9/30/14 → 8/31/17

  Project: Research project

  • Glioma 100%
  • Microglia 33%
  • Kinesin 21%
  • Peptide Hydrolases 13%
  • Organized Financing 9%

• Core C: Imaging and Cell Structure Core

  Snapp, E. L.

  National Institute of Diabetes and Digestive and Kidney Diseases

  8/15/14 → 6/30/16

  Project: Research project

  • image analysis 100%
  • cell structures 98%
  • fluorescent proteins 49%
  • microscopy 47%
  • liver 46%

• Rac1 regulates protrusion and invasion of breast cancers in 3D

  Hodgson, L. & Rose, S. A.

  7/1/14 → 12/31/16

  Project: Research project

  • Podosomes 100%
  • Pseudopodia 67%
  • GTP Phosphohydrolases 51%
  • Adenocarcinoma 17%
  • Breast 17%

• 120kV Transmission Electron Microscope for a Multi-user Microscopy Facility

  Condeelis, J. S. & Rose, S. A.

  6/1/14 → 5/31/16

  Project: Research project

  • transmission electron microscopy 100%
  • transmission electron microscopes 81%
  • image analysis 73%
  • cameras 44%
  • organelles 37%

• Engineering bacterial phytochromes for near-infrared imaging in mammals

  Verkhusha, V. & Rose, S. A.

  5/1/14 → 2/28/19

  Project: Research project

  • phytochrome 100%
  • photoreceptors 61%
  • fluorescent proteins 49%
  • green fluorescent protein 40%
  • probes (equipment) 38%

• Super Resolution PALM/STORM Microscopy System In Multi-User Facility

  Verkhusha, V. & Rose, S. A.

  5/1/14 → 4/30/15

  Project: Research project

  • microscopy 100%
  • light microscopy 57%
  • fluorescent proteins 54%
  • principal investigators 37%
  • image analysis 36%

• Mechanism of Actin mRNA Localization and Localized Translation in Neurons

  Eliscovich, C., Yoon, Y. J., Yoon, Y. J., Rose, S. A., Singer, R. H., Singer, R. H. & Singer, R. H.

  9/15/13 → 8/31/21

  Project: Research project

  • Messenger RNA 100%
  • Actins 53%
  • Proteins 46%
  • Synapses 43%
  • Protein Binding 31%

• Technologies to Define and Map Novel Interorganelle Macromolecular Interactions

  Verkhusha, V., [No Value], N. G., Palmer, A., Snapp, E. L., [No Value], N. G., Snapp, E. L., Verkhusha, V., Rose, S. A., Rose, S. A., Rose, S. A. & Rose, S. A.

  7/1/13 → 4/30/18

  Project: Research project

  • Organelles 100%
  • Macromolecular Substances 48%
  • Proteins 42%
  • Biosensing Techniques 42%
  • Proteomics 31%

• FASEB SRC: From Unfolded Proteins in the Endoplasmic Reticulum to Disease

  Snapp, E. L.

  National Institutes of Health

  6/4/13 → 6/3/14

  Project: Research project

  • Protein Unfolding 100%
  • Endoplasmic Reticulum 98%
  • Protein Folding 69%
  • Proteins 48%
  • Protein Biosynthesis 32%

• Fluorescent probes for quantitation of secretory protein levels in single cells

  Snapp, E. L. & Levy, M.

  9/24/12 → 8/31/15

  Project: Research project

  • Proteins 100%
  • Technology 71%
  • Secretory Pathway 63%
  • Fluorescent Dyes 57%
  • Bacterial Toxins 37%

• Fluorescent probes for quantitation of secretory protein levels in single cells

  Levy, M. & Snapp, E. L.

  National Cancer Institute

  9/24/12 → 8/31/13

  Project: Research project

  • Fluorescent Dyes 100%
  • Proteins 46%
  • Technology 34%
  • Secretory Pathway 24%
  • Bacterial Toxins 21%

• MOLECULAR MECHANISM OF THE CYTOPLASMIC DYNEIN-DYNACTIN MOTOR COMPLEX

  Gennerich, A., Rose, S. A. & Rose, S. A.

  8/1/12 → 3/31/22

  Project: Research project

  • Dyneins 100%
  • Dynactin Complex 65%
  • Cytoplasmic Dyneins 17%
  • Perry Syndrome 7%
  • Microtubules 7%