Abstract
Contact investigations among individuals living with drug-susceptible tuberculosis patients (source cases) have shown a high yield of tuberculosis disease and latent tuberculosis, but the yield of such investigations in households of drug-resistant tuberculosis source cases is unknown. In this systematic review and meta-analysis, we found 25 studies that evaluated a median of 111 (interquartile range, 21-302) household contacts of drug-resistant tuberculosis source cases. The pooled yield was 7.8% (95% CI, 5.6%-10.0%) for active tuberculosis and 47.2% (95% CI, 30.0%-61.4%) for latent tuberculosis, although there was significant statistical heterogeneity (P <. 0001). More than 50% of secondary cases with drug susceptibility test results were concordant with those of the source case. Among studies that followed household members, the majority of secondary cases were detected within 1 year of the source case's diagnosis. Household contact investigation around drug-resistant tuberculosis patients is a high-yield intervention for detection of drug-resistant tuberculosis and prevention of ongoing transmission.
Original language | English (US) |
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Pages (from-to) | 381-391 |
Number of pages | 11 |
Journal | Clinical Infectious Diseases |
Volume | 58 |
Issue number | 3 |
DOIs | |
State | Published - Feb 2014 |
Keywords
- contact
- drug resistance
- transmission
- tuberculosis
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases