TY - JOUR
T1 - Xenotransplantation rejection is antibody-mediated in both sensitized and nonsensitized recipients
AU - Marino, Ignazio Roberto
AU - Celli, Susanna
AU - Catena, Marco
AU - Gatti, Stefano
AU - Zetti, Giorgio
AU - Ferla, Gianfranco
AU - Doyle, Howard R.
AU - Maggiano, Nicola
AU - Musiani, Piero
N1 - Funding Information:
We would like to express our gratitude to Dinangelo Galmarini, MD, Director of the Liver Transplant Unit of the University of Milan, for his continued support. He made this study possible by allowing us to use the Laboratory for Small Animals at the Experimental Surgery Facility of the Liver transplant Unit of the University of Milan. We also thank Ms. Donna Ross for her valuable assistance in preparing the manuscript. This study was partially supported by CNR Target Project-“Biotechnology and Bioinstrumentation.” Address correspondence to lgnazio R. Marino, MD, 3601 Fifth Avenue, Suite 5C, Pittsburgh, PA 15213.
PY - 1994
Y1 - 1994
N2 - This study analyzes the mechanisms involved in xenotransplantation rejection between closely related species. Hamster hearts were transplanted heterotopically into both normal rats and rats previously sensitized by the transfusion of donor blood. Sequential ultrastructural and immunohistochemical analyses were performed on the grafts, spleens, and sera. The data obtained support the view that induced antibodies directed against the xenograft endothelium play a very important role in producing graft damage. Moreover, the demonstration of antibodies against myocyte determinants suggests that it is possible, in this particular model, that the antiendothelial antibodies are not the only ones involved in the injury process.
AB - This study analyzes the mechanisms involved in xenotransplantation rejection between closely related species. Hamster hearts were transplanted heterotopically into both normal rats and rats previously sensitized by the transfusion of donor blood. Sequential ultrastructural and immunohistochemical analyses were performed on the grafts, spleens, and sera. The data obtained support the view that induced antibodies directed against the xenograft endothelium play a very important role in producing graft damage. Moreover, the demonstration of antibodies against myocyte determinants suggests that it is possible, in this particular model, that the antiendothelial antibodies are not the only ones involved in the injury process.
KW - Hamster-to-rat transplant
KW - Heart xenotransplantation
KW - Xenotransplantation
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U2 - 10.3109/08941939409015355
DO - 10.3109/08941939409015355
M3 - Article
C2 - 8049174
AN - SCOPUS:0028197640
SN - 0894-1939
VL - 7
SP - 111
EP - 122
JO - Journal of Investigative Surgery
JF - Journal of Investigative Surgery
IS - 2
ER -