Why Gilgamesh failed: the mechanistic basis of the limits to human lifespan

Brandon Milholland; Jan Vijg

doi:10.1038/s43587-022-00291-z

Why Gilgamesh failed: the mechanistic basis of the limits to human lifespan

Brandon Milholland, Jan Vijg

Genetics

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The purpose of this Perspective is to clarify for an interdisciplinary audience the fundamental concepts of human longevity and provide evidence for a limit to human lifespan. This observed limit is placed into a broader framework by showing how it has arisen through the process of evolution and by enumerating the molecular mechanisms that may enforce it. Finally, we look toward potential future developments and the prospects for possibly circumventing the current limit.

Original language	English (US)
Pages (from-to)	878-884
Number of pages	7
Journal	Nature Aging
Volume	2
Issue number	10
DOIs	https://doi.org/10.1038/s43587-022-00291-z
State	Published - Oct 2022

ASJC Scopus subject areas

Geriatrics and Gerontology
Aging
Neuroscience (miscellaneous)

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10.1038/s43587-022-00291-z

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Why Gilgamesh failed: the mechanistic basis of the limits to human lifespan

Abstract

ASJC Scopus subject areas

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