When lysosomes get old

Ana Maria Cuervo, J. Fred Dice

Research output: Contribution to journalReview articlepeer-review

198 Scopus citations


Changes in the lysosomes of senescent tissues and organisms are common and have been used as biomarkers of aging. Lysosomes are responsible for the degradation of many macromolecules, including proteins. At least five different pathways for the delivery of substrate proteins to lysosomes are known. Three of these pathways decline with age, and the molecular explanations for these deficiencies are currently being studied. Other aspects of lysosomal proteolysis increase or do not change with age in spite of marked changes in lysosomal morphology and biochemistry. Age-related changes in certain lysosomal pathways of proteolysis remain to be studied. This area of research is important because abnormalities in lysosomal protein degradation pathways may contribute to several characteristics and pathologies associated with aging. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)119-131
Number of pages13
JournalExperimental Gerontology
Issue number2
StatePublished - Mar 2000
Externally publishedYes


  • Aging
  • Endosomal system
  • Lipofuscin deposits
  • Lysosomal
  • Protein degradation
  • Senescence
  • β-amyloid deposits

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology


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