Watching single protons bind

Research output: Contribution to journalShort surveypeer-review


Using single-molecule biophysical studies in an ion channel, the protonation state of engineered basic amino acids was measured in real time, making it possible to calculate the pKas of the substituted residues and creating a unique, comprehensive dataset for theorists studying the effects of an electrostatic environment on integral membrane protein function.

Original languageEnglish (US)
Pages (from-to)128-130
Number of pages3
JournalNature Chemical Biology
Issue number3
StatePublished - Mar 2006

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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