TY - JOUR
T1 - Walking the walk
T2 - how kinesin and dynein coordinate their steps
AU - Gennerich, Arne
AU - Vale, Ronald D.
PY - 2009/2
Y1 - 2009/2
N2 - Molecular motors drive key biological processes such as cell division, intracellular organelle transport, and sperm propulsion and defects in motor function can give rise to various human diseases. Two dimeric microtubule-based motor proteins, kinesin-1 and cytoplasmic dynein can take over one hundred steps without detaching from the track. In this review, we discuss how these processive motors coordinate the activities of their two identical motor domains so that they can walk along microtubules.
AB - Molecular motors drive key biological processes such as cell division, intracellular organelle transport, and sperm propulsion and defects in motor function can give rise to various human diseases. Two dimeric microtubule-based motor proteins, kinesin-1 and cytoplasmic dynein can take over one hundred steps without detaching from the track. In this review, we discuss how these processive motors coordinate the activities of their two identical motor domains so that they can walk along microtubules.
UR - http://www.scopus.com/inward/record.url?scp=60749121148&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=60749121148&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2008.12.002
DO - 10.1016/j.ceb.2008.12.002
M3 - Review article
C2 - 19179063
AN - SCOPUS:60749121148
SN - 0955-0674
VL - 21
SP - 59
EP - 67
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 1
ER -
