Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: Behavioral and biochemical evidence

Jean Lud Cadet; Mindy Katz; Vernice Jackson-Lewis; Stanley Fahn

doi:10.1016/0006-8993(89)91530-8

Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: Behavioral and biochemical evidence

Jean Lud Cadet, Mindy Katz, Vernice Jackson-Lewis, Stanley Fahn

Research output: Contribution to journal › Article › peer-review

151 Scopus citations

Abstract

Unilateral 6-hydroxydopamine (6-OHDA) injections into the striatum lead to the development of apomorphine-induced rotation in rats. The circling behavior was associated with significant decreases in dopamine, dihydroxyphenylacetic acid and homovanillic acid in the ipsilateral striatum. Pretreatments with either d-a-tocopherol or all-racemic-a-tocopherol caused significant attenuation of both the behavioral and biochemical abnormalities. These results are discussed in terms of their support for the three radical hypothesis of Parkinson's disease and for the role of antioxidants in the treatment of this neurodegenerative disorder.

Original language	English (US)
Pages (from-to)	10-15
Number of pages	6
Journal	Brain research
Volume	476
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(89)91530-8
State	Published - Jan 2 1989
Externally published	Yes

Keywords

6-Hydroxydopamine
Antioxidant
Free radical
Parkinson's disease
Rotation
Striatum
α-Tocopherol

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(89)91530-8

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abstract = "Unilateral 6-hydroxydopamine (6-OHDA) injections into the striatum lead to the development of apomorphine-induced rotation in rats. The circling behavior was associated with significant decreases in dopamine, dihydroxyphenylacetic acid and homovanillic acid in the ipsilateral striatum. Pretreatments with either d-a-tocopherol or all-racemic-a-tocopherol caused significant attenuation of both the behavioral and biochemical abnormalities. These results are discussed in terms of their support for the three radical hypothesis of Parkinson's disease and for the role of antioxidants in the treatment of this neurodegenerative disorder.",

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AU - Katz, Mindy

AU - Jackson-Lewis, Vernice

AU - Fahn, Stanley

PY - 1989/1/2

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AB - Unilateral 6-hydroxydopamine (6-OHDA) injections into the striatum lead to the development of apomorphine-induced rotation in rats. The circling behavior was associated with significant decreases in dopamine, dihydroxyphenylacetic acid and homovanillic acid in the ipsilateral striatum. Pretreatments with either d-a-tocopherol or all-racemic-a-tocopherol caused significant attenuation of both the behavioral and biochemical abnormalities. These results are discussed in terms of their support for the three radical hypothesis of Parkinson's disease and for the role of antioxidants in the treatment of this neurodegenerative disorder.

KW - 6-Hydroxydopamine

KW - Antioxidant

KW - Free radical

KW - Parkinson's disease

KW - Rotation

KW - Striatum

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Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: Behavioral and biochemical evidence

Abstract

Keywords

ASJC Scopus subject areas

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