Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

Michelle M. Pacis, Chelsea N. Fortin, Shvetha M. Zarek, Sunni L. Mumford, James H. Segars

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Purpose: To review the current literature regarding the role of vitamin D status in pregnancy outcomes in women undergoing assisted reproductive technology (ART) and to assess cost-effectiveness of routine vitamin D deficiency screening and repletion prior to initiation of ART. Methods: A systematic literature review was conducted using PubMed. Relevant study outcomes were compared among the selected studies. A cost-benefit analysis was performed using a decision tree mathematical model with sensitivity analyses from the perspective of direct societal cost. Published data were used to estimate probabilities and costs in 2014 US dollars. Results: Thirty-four articles were retrieved, of which eight met inclusion criteria. One study demonstrated a negative relationship between vitamin D status and ART outcomes, while two studies showed no association. The remaining five studies concluded that ART outcomes improved after vitamin D repletion. Conclusion: The majority of reviewed studies reported a decrement in ART outcomes in patients with vitamin D deficiency. Cost-benefit analyses suggested that screening and supplementing vitamin D prior to ART might be cost effective, but further evidence is needed. Given the absence of Level I evidence regarding vitamin D status and ART outcomes, full endorsement of routine vitamin D screening and supplementation prior to ART is premature.

Original languageEnglish (US)
Pages (from-to)323-335
Number of pages13
JournalJournal of Assisted Reproduction and Genetics
Issue number3
StatePublished - Mar 18 2015
Externally publishedYes


  • ART
  • Assisted reproductive technology
  • IVF
  • In vitro fertilization
  • Vitamin D

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Genetics(clinical)


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