Vitamin C and cardiovascular disease: An update

Marco B. Morelli; Jessica Gambardella; Vanessa Castellanos; Valentina Trimarco; Gaetano Santulli

doi:10.3390/antiox9121227

Vitamin C and cardiovascular disease: An update

Marco B. Morelli, Jessica Gambardella, Vanessa Castellanos, Valentina Trimarco, Gaetano Santulli

Medicine

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

The potential beneficial effects of the antioxidant properties of vitamin C have been investigated in a number of pathological conditions. In this review, we assess both clinical and preclinical studies evaluating the role of vitamin C in cardiac and vascular disorders, including coronary heart disease, heart failure, hypertension, and cerebrovascular diseases. Pitfalls and controversies in investigations on vitamin C and cardiovascular disorders are also discussed.

Original language	English (US)
Article number	1227
Pages (from-to)	1-23
Number of pages	23
Journal	Antioxidants
Volume	9
Issue number	12
DOIs	https://doi.org/10.3390/antiox9121227
State	Published - Dec 2020

Keywords

Ascorbic acid
Blood pressure
COVID–19
Coronavirus
Dietary supplements
Drug formulations
Endothelial dysfunction
GULO
Heart failure
Hypertension
Infections
Liposomes
Oxidative stress
SVCT
Stroke
Vascular permeability
Vitamin C

ASJC Scopus subject areas

Food Science
Physiology
Biochemistry
Molecular Biology
Clinical Biochemistry
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/antiox9121227

Cite this

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title = "Vitamin C and cardiovascular disease: An update",

abstract = "The potential beneficial effects of the antioxidant properties of vitamin C have been investigated in a number of pathological conditions. In this review, we assess both clinical and preclinical studies evaluating the role of vitamin C in cardiac and vascular disorders, including coronary heart disease, heart failure, hypertension, and cerebrovascular diseases. Pitfalls and controversies in investigations on vitamin C and cardiovascular disorders are also discussed.",

keywords = "Ascorbic acid, Blood pressure, COVID–19, Coronavirus, Dietary supplements, Drug formulations, Endothelial dysfunction, GULO, Heart failure, Hypertension, Infections, Liposomes, Oxidative stress, SVCT, Stroke, Vascular permeability, Vitamin C",

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doi = "10.3390/antiox9121227",

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AU - Morelli, Marco B.

AU - Gambardella, Jessica

AU - Castellanos, Vanessa

AU - Trimarco, Valentina

AU - Santulli, Gaetano

PY - 2020/12

Y1 - 2020/12

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AB - The potential beneficial effects of the antioxidant properties of vitamin C have been investigated in a number of pathological conditions. In this review, we assess both clinical and preclinical studies evaluating the role of vitamin C in cardiac and vascular disorders, including coronary heart disease, heart failure, hypertension, and cerebrovascular diseases. Pitfalls and controversies in investigations on vitamin C and cardiovascular disorders are also discussed.

KW - Ascorbic acid

KW - Blood pressure

KW - COVID–19

KW - Coronavirus

KW - Dietary supplements

KW - Drug formulations

KW - Endothelial dysfunction

KW - GULO

KW - Heart failure

KW - Hypertension

KW - Infections

KW - Liposomes

KW - Oxidative stress

KW - SVCT

KW - Stroke

KW - Vascular permeability

KW - Vitamin C

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Vitamin C and cardiovascular disease: An update

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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