Vitamin C and cardiovascular disease: An update

Marco B. Morelli, Jessica Gambardella, Vanessa Castellanos, Valentina Trimarco, Gaetano Santulli

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


The potential beneficial effects of the antioxidant properties of vitamin C have been investigated in a number of pathological conditions. In this review, we assess both clinical and preclinical studies evaluating the role of vitamin C in cardiac and vascular disorders, including coronary heart disease, heart failure, hypertension, and cerebrovascular diseases. Pitfalls and controversies in investigations on vitamin C and cardiovascular disorders are also discussed.

Original languageEnglish (US)
Article number1227
Pages (from-to)1-23
Number of pages23
Issue number12
StatePublished - Dec 2020


  • Ascorbic acid
  • Blood pressure
  • COVID–19
  • Coronavirus
  • Dietary supplements
  • Drug formulations
  • Endothelial dysfunction
  • GULO
  • Heart failure
  • Hypertension
  • Infections
  • Liposomes
  • Oxidative stress
  • SVCT
  • Stroke
  • Vascular permeability
  • Vitamin C

ASJC Scopus subject areas

  • Food Science
  • Physiology
  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology


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