TY - JOUR
T1 - Variations in the synthesis and assembly of immunoglobulins by mouse myeloma cells
T2 - A genetic and biochemical analysis
AU - Scharff, M. D.
AU - Bargellesi, A.
AU - Baumal, R.
AU - Buxbaum, J.
AU - Coffino, P.
AU - Laskov, R.
PY - 1970/12
Y1 - 1970/12
N2 - The synthesis, assembly, and secretion of gamma globulin has been examined using cells from a mouse plasma cell tumor. The cells were then adapted to continuous culture and individual clones were obtained which differed from each other in the relative amounts of heavy and light chains synthesized, in the absolute amounts of gamma globulin being produced, and in the details of the assembly process. Finally, the kinetics, pathway, and completeness of assembly were examined in a variety of tumors and variants of these tumors.
AB - The synthesis, assembly, and secretion of gamma globulin has been examined using cells from a mouse plasma cell tumor. The cells were then adapted to continuous culture and individual clones were obtained which differed from each other in the relative amounts of heavy and light chains synthesized, in the absolute amounts of gamma globulin being produced, and in the details of the assembly process. Finally, the kinetics, pathway, and completeness of assembly were examined in a variety of tumors and variants of these tumors.
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U2 - 10.1002/jcp.1040760311
DO - 10.1002/jcp.1040760311
M3 - Article
C2 - 4100579
AN - SCOPUS:0014912696
SN - 0021-9541
VL - 76
SP - 331
EP - 348
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
IS - 3
ER -