Validation of a Rheumatoid Arthritis Health-Related Quality of Life Instrument, the CSHQ-RA

S. M. Russak, C. D. Sherbourne, D. P. Lubeck, H. D. Paulus, C. F. Chiou, N. Sengupta, J. Borenstein, J. Ofman, A. Moadel, M. H. Weisman

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Objective. To test the validity and reliability of a newly developed disease-specific multidimensional quality of life instrument: the Cedars-Sinai Health-Related Quality of Life Instrument (CSHQ-RA). Methods. A total of 350 rheumatoid arthritis (RA) patients were asked to complete the CSHQ-RA at 2 time points (4 weeks apart). Patients also completed the Medical Outcomes Study Short Form 36 (SF-36) and the Stanford Health Assessment Questionnaire (HAQ) Disability Index (DI) at the second time point. Construct validity was tested, using Pearson's correlations, by comparing subscale scores on the CSHQ-RA to those obtained from the mental component summary (MCS) and physical component summary (PCS) of the SF-36. HAQ DI scores were used to assess the discriminant validity of the CSHQ-RA. Intraclass correlation coefficients (ICCs) were used to assess test-retest reliability. Results. Response rates for the first and second survey were 83% (291) and 93% (276), respectively; 84% of respondents were women, and mean age was 57 years. Mean scores ± SDs on instruments were: HAQ 0.73 ± 0.69; MCS 49 ± 12; and PCS 33 ± 11. Pearson's correlations between the CSHQ-RA subscale scores and the SF-36 scores ranged from 0.55 to 0.76 (P < 0.001). Analysis of variance indicate that scores on the CSHQ-RA discriminated between levels of physical disability as measured by the HAQ (P < 0.001). Test-retest reliability was demonstrated in the instrument's subscale scores (ICC 0.70-0.90). Conclusion. These results support the construct validity, discriminant validity, and reliability of the CSHQ-RA as a measure that captures the impact of RA on patients' health-related quality of life.

Original languageEnglish (US)
Pages (from-to)798-803
Number of pages6
JournalArthritis Care and Research
Issue number6
StatePublished - Dec 15 2003


  • Assessment tool
  • Quality of life
  • Rheumatoid arthritis
  • Validation

ASJC Scopus subject areas

  • Rheumatology


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