Vaccine efficacy of a lysine auxotroph of Mycobacterium tuberculosis

Martin S. Pavelka, Bing Chen, Cynthia L. Kelley, Frank M. Collins, William R. Jacobs

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


The in vivo growth phenotype and vaccine efficacy of a lysine auxotrophic mutant of Mycobacterium tuberculosis strain H37Rv are described. An immunization experiment using a mouse model with an aerosol challenge showed that two doses of the M. tuberculosis mutant were required to generate protection equivalent to that of the Mycobacterium bovis BCG vaccine.

Original languageEnglish (US)
Pages (from-to)4190-4192
Number of pages3
JournalInfection and immunity
Issue number7
StatePublished - Jul 1 2003

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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