Vaccine development. On relating immunology to the Third World: Some studies on leprosy

B. R. Bloom, P. Salgame, V. Mehra, H. Kato, R. Modlin, T. Rea, P. Brennan, J. Convit, L. Lugozi, S. Snapper, W. Jacobs

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Leprosy is of interest to immunologists because the varied clinical manifestations of the disease correlate closely with the immunological spectrum. Resistance to infection is dependent on appropriate cell-mediated immunity, but patients with the lepromatous form fail to respond to antigen of M. leprae. In vitro studies have revealed the existence of T-suppressor cells of the phenotype CD8+, CD3+, HLA-DR+, FcR+, 9.3-, which are restricted by major histocompatibility complex (MHC) class II antigens. Several new candidate vaccines against leprosy have been effective in breaking immunological unresponsiveness and engendering cell-mediated immunity in lepromatous leprosy patients, including the combination of BCG + killed M. leprae. Because BCG has unique adjuvant properties, we have begun to use molecular genetic approaches to develop BCG into a multivaccine vehicle capable of immunizing simultaneously against several pathogens. Both phage-based and plasmid-based strategies have been developed for introducing selectable markers into BCG for the first time.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
Issue numberSUPPL. 2
StatePublished - 1989

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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