Uterine sarcoma with ambiguous histomorphology: A case report

Eirwen M. Miller, Yumei Fu, Ruben Barrera Vera, Gary L. Goldberg, Rouzan G. Karabakhtsian

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background Leiomyosarcomas (LMS) and endometrial stromal sarcomas (ESS) may display overlapping histomorphology, which may challenge diagnostic accuracy. Since LMS and ESS have vastly different clinical behavior and adjuvant therapy recommendations, accurate diagnosis is critical. Case We present the case of an 83-year-old female with postmenopausal bleeding who underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy for clinically atypical appearing leiomyomata. Histologically, dual populations of cells with morphologic features of low-grade ESS and high-grade spindle cell sarcoma were seen. Immunohistochemistry and molecular studies revealed the cells to be of smooth muscle derivation, rendering a diagnosis of high-grade LMS with heterogeneous morphology (stage IB). The patient received adjuvant gemcitabine plus docetaxel. She recurred 8 months after completion of chemotherapy and was transferred to hospice care. Conclusion Ancillary studies, such as immunohistochemistry and molecular testing, aid in accurate subcategorization of uterine sarcomas with ambiguous histomorphology.

Original languageEnglish (US)
Pages (from-to)30-33
Number of pages4
JournalGynecologic Oncology Reports
StatePublished - May 1 2017


  • Endometrial stromal sarcoma
  • Histomorphology
  • Immunohistochemistry
  • Leiomyosarcoma
  • Molecular testing
  • Uterine sarcoma

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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