Use of molecular biomarkers in FNA specimens to personalize treatment for thyroid surgery

Vikas Mehta; Yuri E. Nikiforov; Robert L. Ferris

doi:10.1002/hed.23140

Use of molecular biomarkers in FNA specimens to personalize treatment for thyroid surgery

Vikas Mehta, Yuri E. Nikiforov, Robert L. Ferris

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Background: Accurate preoperative assessment of thyroid nodules with fine-needle aspiration biopsy (FNAB) continues to be a challenge, often resulting in unnecessary diagnostic surgical intervention. The detection of several novel gene mutations in differentiated thyroid cancer (DTC) over the last decade has led to the diagnostic use of these oncogenic alterations to improve FNAB sensitivity and specificity. Methods and Results: Thyroid oncogene mutations including BRAF, RAS, and RET/PTC are reviewed. The potential benefit of using this panel on fine-needle aspiration (FNA) cytology samples will be described. Conclusion: Our use of ''reflexive'' molecular testing demonstrates its clinical value in conjunction with FNAB cytology, representing an application of personalized molecular medicine to guide appropriate surgical therapy.

Original language	English (US)
Pages (from-to)	1499-1506
Number of pages	8
Journal	Head and Neck
Volume	35
Issue number	10
DOIs	https://doi.org/10.1002/hed.23140
State	Published - Oct 2013
Externally published	Yes

Keywords

Thyroid
biomarkers
diagnosis
molecular testing
prognosis

ASJC Scopus subject areas

Otorhinolaryngology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.23140

Cite this

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abstract = "Background: Accurate preoperative assessment of thyroid nodules with fine-needle aspiration biopsy (FNAB) continues to be a challenge, often resulting in unnecessary diagnostic surgical intervention. The detection of several novel gene mutations in differentiated thyroid cancer (DTC) over the last decade has led to the diagnostic use of these oncogenic alterations to improve FNAB sensitivity and specificity. Methods and Results: Thyroid oncogene mutations including BRAF, RAS, and RET/PTC are reviewed. The potential benefit of using this panel on fine-needle aspiration (FNA) cytology samples will be described. Conclusion: Our use of ''reflexive'' molecular testing demonstrates its clinical value in conjunction with FNAB cytology, representing an application of personalized molecular medicine to guide appropriate surgical therapy.",

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T1 - Use of molecular biomarkers in FNA specimens to personalize treatment for thyroid surgery

AU - Mehta, Vikas

AU - Nikiforov, Yuri E.

AU - Ferris, Robert L.

PY - 2013/10

Y1 - 2013/10

N2 - Background: Accurate preoperative assessment of thyroid nodules with fine-needle aspiration biopsy (FNAB) continues to be a challenge, often resulting in unnecessary diagnostic surgical intervention. The detection of several novel gene mutations in differentiated thyroid cancer (DTC) over the last decade has led to the diagnostic use of these oncogenic alterations to improve FNAB sensitivity and specificity. Methods and Results: Thyroid oncogene mutations including BRAF, RAS, and RET/PTC are reviewed. The potential benefit of using this panel on fine-needle aspiration (FNA) cytology samples will be described. Conclusion: Our use of ''reflexive'' molecular testing demonstrates its clinical value in conjunction with FNAB cytology, representing an application of personalized molecular medicine to guide appropriate surgical therapy.

AB - Background: Accurate preoperative assessment of thyroid nodules with fine-needle aspiration biopsy (FNAB) continues to be a challenge, often resulting in unnecessary diagnostic surgical intervention. The detection of several novel gene mutations in differentiated thyroid cancer (DTC) over the last decade has led to the diagnostic use of these oncogenic alterations to improve FNAB sensitivity and specificity. Methods and Results: Thyroid oncogene mutations including BRAF, RAS, and RET/PTC are reviewed. The potential benefit of using this panel on fine-needle aspiration (FNA) cytology samples will be described. Conclusion: Our use of ''reflexive'' molecular testing demonstrates its clinical value in conjunction with FNAB cytology, representing an application of personalized molecular medicine to guide appropriate surgical therapy.

KW - Thyroid

KW - biomarkers

KW - diagnosis

KW - molecular testing

KW - prognosis

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Use of molecular biomarkers in FNA specimens to personalize treatment for thyroid surgery

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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