Use of diffusion-weighted imaging in recurrent central nervous system Whipple's disease: a case report and review of the literature

Amit A. Raheja; Yvonne W. Lui; Alberto Pinzon-Ardila; Ruth P. Lim; Steven A. Sparr

doi:10.1016/j.clinimag.2009.05.011

Use of diffusion-weighted imaging in recurrent central nervous system Whipple's disease: a case report and review of the literature

Amit A. Raheja, Yvonne W. Lui, Alberto Pinzon-Ardila, Ruth P. Lim, Steven A. Sparr

Neurology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A case of Whipple's disease with development of antibiotic resistance is reported. The patient's symptomatology correlated with evolution of diffusion abnormality rather than with lesion enhancement. The lesion demonstrated no hyperperfusion, moderately elevated choline, and decreased N-acetylaspartate. Conventional magnetic resonance (MR) imaging findings of central nervous system Whipple's disease are nonspecific and may mimic neoplasm. MR perfusion and spectroscopy findings are reported, which may assist in diagnosis. Change in diffusion restriction appears to be a potential imaging indicator of clinical progression and response to therapy.

Original language	English (US)
Pages (from-to)	143-147
Number of pages	5
Journal	Clinical Imaging
Volume	34
Issue number	2
DOIs	https://doi.org/10.1016/j.clinimag.2009.05.011
State	Published - Mar 2010

Keywords

Central nervous system
Diffusion
Infection
Magnetic resonance imaging
Whipple's disease

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1016/j.clinimag.2009.05.011

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abstract = "A case of Whipple's disease with development of antibiotic resistance is reported. The patient's symptomatology correlated with evolution of diffusion abnormality rather than with lesion enhancement. The lesion demonstrated no hyperperfusion, moderately elevated choline, and decreased N-acetylaspartate. Conventional magnetic resonance (MR) imaging findings of central nervous system Whipple's disease are nonspecific and may mimic neoplasm. MR perfusion and spectroscopy findings are reported, which may assist in diagnosis. Change in diffusion restriction appears to be a potential imaging indicator of clinical progression and response to therapy.",

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AU - Pinzon-Ardila, Alberto

AU - Lim, Ruth P.

AU - Sparr, Steven A.

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AB - A case of Whipple's disease with development of antibiotic resistance is reported. The patient's symptomatology correlated with evolution of diffusion abnormality rather than with lesion enhancement. The lesion demonstrated no hyperperfusion, moderately elevated choline, and decreased N-acetylaspartate. Conventional magnetic resonance (MR) imaging findings of central nervous system Whipple's disease are nonspecific and may mimic neoplasm. MR perfusion and spectroscopy findings are reported, which may assist in diagnosis. Change in diffusion restriction appears to be a potential imaging indicator of clinical progression and response to therapy.

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KW - Diffusion

KW - Infection

KW - Magnetic resonance imaging

KW - Whipple's disease

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Use of diffusion-weighted imaging in recurrent central nervous system Whipple's disease: a case report and review of the literature

Abstract

Keywords

ASJC Scopus subject areas

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