TY - JOUR
T1 - Urokinase receptor and integrin partnership
T2 - Coordination of signaling for cell adhesion, migration and growth
AU - Ossowski, Liliana
AU - Aguirre-Ghiso, Julio A.
N1 - Funding Information:
This work was supported by a US Public Health Service Research Grant (CA-40758) and the Samuel Waxman Cancer Research Foundation. This article was not meant to be a comprehensive review of the existing literature and because of space constraints not all the relevant work has been included. We apologize in advance for what were not intentional omissions. Some topics, such as the role of uPAR in adhesion to vitronectin, have not been discussed.
PY - 2000
Y1 - 2000
N2 - Urokinase-type plasminogen activator receptor (uPAR) binds the urokinase-type plasminogen activator (uPA) and facilitates a proteolytic cascade focused at the cell surface. More recently, uPAR was recognized as a multifunctional protein that, through its interactions with integrins, initiates signaling events that alter cell adhesion, migration and proliferation. Results obtained recently have led to new insights into the structural aspects of uPAR interaction with integrins, provided a more detailed description of the signaling pathway they induce, and determined that uPAR signaling plays a role in cell migration and tumorigenicity.
AB - Urokinase-type plasminogen activator receptor (uPAR) binds the urokinase-type plasminogen activator (uPA) and facilitates a proteolytic cascade focused at the cell surface. More recently, uPAR was recognized as a multifunctional protein that, through its interactions with integrins, initiates signaling events that alter cell adhesion, migration and proliferation. Results obtained recently have led to new insights into the structural aspects of uPAR interaction with integrins, provided a more detailed description of the signaling pathway they induce, and determined that uPAR signaling plays a role in cell migration and tumorigenicity.
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U2 - 10.1016/S0955-0674(00)00140-X
DO - 10.1016/S0955-0674(00)00140-X
M3 - Review article
C2 - 10978898
AN - SCOPUS:0033824172
SN - 0955-0674
VL - 12
SP - 613
EP - 620
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 5
ER -