Updates on adjuvant chemotherapy and radiation therapy for endometrial cancer

Matthew Cowan, Jonathan B. Strauss, Emma L. Barber, Daniela Matei

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Purpose of reviewThis article will provide an opinion on adjuvant treatment of stage I-III endometrial cancer based on existing and evolving evidence.Recent findingsFor early-stage (I and II) intermediate risk endometrial cancer, vaginal brachytherapy reduces the risk of locoregional relapse. Recent studies have investigated the use of chemotherapy in early stage, high-risk patient population, but did not demonstrate a survival benefit. As such, chemotherapy is only recommended for selected patients at high risk for distant recurrence. On the other hand, for stage III disease, chemotherapy has a well established role. A landmark trial recently reported confirmed that chemoradiation improves recurrence-free survival compared with radiation alone in stage III endometrial cancer. However, in another randomized phase III trial, chemoradiotherapy was not superior to chemotherapy alone in this group, raising questions as to whether addition of radiation is necessary. Therefore, improved risk stratification using molecular markers in addition to traditional pathological criteria is critically needed to better predict the risk of local and systemic recurrence and to assist therapy decision-making.SummaryEndometrial cancer care is evolving and recent pivotal trials highlight the significance of chemotherapy to the treatment of stage III endometrial cancer and not to the approach for stage I and II cancer. The role of radiation therapy for stage III disease is raised into question.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalCurrent Opinion in Obstetrics and Gynecology
Issue number1
StatePublished - Feb 1 2019
Externally publishedYes


  • chemotherapy
  • endometrial cancer
  • immunotherapy
  • molecular markers
  • radiation therapy

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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