TY - JOUR
T1 - Unusual presentation of graft-versus-host disease in pediatric liver transplant recipients
T2 - Evidence of late and recurrent disease
AU - Pinna, Antonio D.
AU - Weppler, Deborah
AU - Berho, Mariana
AU - Masetti, Michele
AU - DeFaria, Werviston
AU - Kato, Tomoaki
AU - Thompson, John
AU - Ricordi, Camillo
AU - Tzakis, Andreas G.
PY - 1999/8
Y1 - 1999/8
N2 - Graft-versus-host disease (GvHD) is a multi-organ disease caused by mature donor T cells that are activated by alloantigens expressed by the host antigen-presenting cells. GvHD has been reported after solid organ transplantation with two principal presentations: humoral and cellular. In the cellular type of GvHD after liver transplantation the symptoms are identical to the GvHD after bone marrow transplant, except that the liver is spared because it lacks host antigens. We have described three cases of intestinal GvHD after pediatric liver transplant with an unusual recurrent late presentation in two patients. Two patients were female, and their age at the time of transplant was 8 and 9 months, respectively, and one was an 8- month-old male. They all received reduced liver allografts of identical blood type from three different donors. One patient received two doses of donor bone marrow cell infusion. Two patients received double immunosuppressive therapy constituted by tacrolimus at a dose of 0.05 mg/kg p.o.b.i.d, and steroids 10 mg p.o. daily. One patient received a triple drug immunosuppression with tacrolimus (0.05 mg/kg p.o. b.i.d.), steroids (10 mg p.o. daily) and mycophenolate mofetil (125 mg p.o.b.i.d.). Diagnosis of intestinal GvHD was confirmed histologically on intestinal biopsies performed at the time of presentation of the clinical symptoms or at autopsy.
AB - Graft-versus-host disease (GvHD) is a multi-organ disease caused by mature donor T cells that are activated by alloantigens expressed by the host antigen-presenting cells. GvHD has been reported after solid organ transplantation with two principal presentations: humoral and cellular. In the cellular type of GvHD after liver transplantation the symptoms are identical to the GvHD after bone marrow transplant, except that the liver is spared because it lacks host antigens. We have described three cases of intestinal GvHD after pediatric liver transplant with an unusual recurrent late presentation in two patients. Two patients were female, and their age at the time of transplant was 8 and 9 months, respectively, and one was an 8- month-old male. They all received reduced liver allografts of identical blood type from three different donors. One patient received two doses of donor bone marrow cell infusion. Two patients received double immunosuppressive therapy constituted by tacrolimus at a dose of 0.05 mg/kg p.o.b.i.d, and steroids 10 mg p.o. daily. One patient received a triple drug immunosuppression with tacrolimus (0.05 mg/kg p.o. b.i.d.), steroids (10 mg p.o. daily) and mycophenolate mofetil (125 mg p.o.b.i.d.). Diagnosis of intestinal GvHD was confirmed histologically on intestinal biopsies performed at the time of presentation of the clinical symptoms or at autopsy.
KW - Intestinal graft-versus-host disease
KW - Liver transplantation
KW - Pediatrics
UR - http://www.scopus.com/inward/record.url?scp=0032796714&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032796714&partnerID=8YFLogxK
U2 - 10.1034/j.1399-3046.1999.00043.x
DO - 10.1034/j.1399-3046.1999.00043.x
M3 - Article
C2 - 10487286
AN - SCOPUS:0032796714
SN - 1397-3142
VL - 3
SP - 236
EP - 242
JO - Pediatric Transplantation
JF - Pediatric Transplantation
IS - 3
ER -