Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2

Eeva Liisa Eskelinen; Ana Maria Cuervo; Matthew R.G. Taylor; Ichizo Nishino; Janice S. Blum; J. Fred Dice; Ignacio V. Sandoval; Jennifer Lippincott-Schwartz; J. Thomas August; Paul Saftig

doi:10.1111/j.1600-0854.2005.00337.x

Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2

Eeva Liisa Eskelinen, Ana Maria Cuervo, Matthew R.G. Taylor, Ichizo Nishino, Janice S. Blum, J. Fred Dice, Ignacio V. Sandoval, Jennifer Lippincott-Schwartz, J. Thomas August, Paul Saftig

Developmental & Molecular Biology

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

The present nomenclature of the splice variants of the lysosome-associated membrane protein type 2 (LAMP-2) is confusing. The LAMP-2a isoform is uniformly named in human, chicken, and mouse, but the LAMP-2b and LAMP-2c isoforms are switched in human as compared with mouse and chicken. We propose to change the nomenclature of the chicken and mouse b and c isoforms to agree with that currently used for the human isoforms. To avoid confusion in the literature, we further propose to adopt the use of capital letters for the updated nomenclature of all the isoforms in all three species: LAMP-2A, LAMP-2B, and LAMP-2C.

Original language	English (US)
Pages (from-to)	1058-1061
Number of pages	4
Journal	Traffic
Volume	6
Issue number	11
DOIs	https://doi.org/10.1111/j.1600-0854.2005.00337.x
State	Published - Nov 2005

Keywords

Alternative splicing
Isoforms
LAMP-1
LAMP-2
LAMP1
LAMP2
Lysosome

ASJC Scopus subject areas

Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1111/j.1600-0854.2005.00337.x

Cite this

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title = "Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2",

abstract = "The present nomenclature of the splice variants of the lysosome-associated membrane protein type 2 (LAMP-2) is confusing. The LAMP-2a isoform is uniformly named in human, chicken, and mouse, but the LAMP-2b and LAMP-2c isoforms are switched in human as compared with mouse and chicken. We propose to change the nomenclature of the chicken and mouse b and c isoforms to agree with that currently used for the human isoforms. To avoid confusion in the literature, we further propose to adopt the use of capital letters for the updated nomenclature of all the isoforms in all three species: LAMP-2A, LAMP-2B, and LAMP-2C.",

keywords = "Alternative splicing, Isoforms, LAMP-1, LAMP-2, LAMP1, LAMP2, Lysosome",

author = "Eskelinen, {Eeva Liisa} and Cuervo, {Ana Maria} and Taylor, {Matthew R.G.} and Ichizo Nishino and Blum, {Janice S.} and Dice, {J. Fred} and Sandoval, {Ignacio V.} and Jennifer Lippincott-Schwartz and August, {J. Thomas} and Paul Saftig",

year = "2005",

month = nov,

doi = "10.1111/j.1600-0854.2005.00337.x",

language = "English (US)",

volume = "6",

pages = "1058--1061",

journal = "Traffic",

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AU - Eskelinen, Eeva Liisa

AU - Cuervo, Ana Maria

AU - Taylor, Matthew R.G.

AU - Nishino, Ichizo

AU - Blum, Janice S.

AU - Dice, J. Fred

AU - Sandoval, Ignacio V.

AU - Lippincott-Schwartz, Jennifer

AU - August, J. Thomas

AU - Saftig, Paul

PY - 2005/11

Y1 - 2005/11

N2 - The present nomenclature of the splice variants of the lysosome-associated membrane protein type 2 (LAMP-2) is confusing. The LAMP-2a isoform is uniformly named in human, chicken, and mouse, but the LAMP-2b and LAMP-2c isoforms are switched in human as compared with mouse and chicken. We propose to change the nomenclature of the chicken and mouse b and c isoforms to agree with that currently used for the human isoforms. To avoid confusion in the literature, we further propose to adopt the use of capital letters for the updated nomenclature of all the isoforms in all three species: LAMP-2A, LAMP-2B, and LAMP-2C.

AB - The present nomenclature of the splice variants of the lysosome-associated membrane protein type 2 (LAMP-2) is confusing. The LAMP-2a isoform is uniformly named in human, chicken, and mouse, but the LAMP-2b and LAMP-2c isoforms are switched in human as compared with mouse and chicken. We propose to change the nomenclature of the chicken and mouse b and c isoforms to agree with that currently used for the human isoforms. To avoid confusion in the literature, we further propose to adopt the use of capital letters for the updated nomenclature of all the isoforms in all three species: LAMP-2A, LAMP-2B, and LAMP-2C.

KW - Alternative splicing

KW - Isoforms

KW - LAMP-1

KW - LAMP-2

KW - LAMP1

KW - LAMP2

KW - Lysosome

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ER -

Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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