Abstract
Helper T cells become hyporesponsive in the tumor microenvironment (at least in part) owing to the NFAT1-dependent expression of anergy-associated genes. Anergy constitutes a crucial mechanism to prevent tumor destruction by T cells, and hence may represent a powerful target to boost antitumor immune responses and improve the efficacy of immunotherapy.
Original language | English (US) |
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Article number | e22679 |
Journal | OncoImmunology |
Volume | 2 |
Issue number | 2 |
DOIs |
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State | Published - Feb 2013 |
Keywords
- Anergy
- Immune evasion
- Melanoma
- NFAT
- T helper cell
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology