Unconventional NMDA receptor signaling

Kim Dore, Ivar S. Stein, Jennifer A. Brock, Pablo E. Castillo, Karen Zito, P. Jesper Sjöström

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


In the classical view, NMDA receptors (NMDARs) are stably expressed at the postsynaptic membrane, where they act via Ca2+ to signal coincidence detection in Hebbian plasticity. More recently, it has been established that NMDAR-mediated transmission can be dynamically regulated by neural activity. In addition, NMDARs have been found presynaptically, where they cannot act as conventional coincidence detectors. Unexpectedly, NMDARs have also been shown to signal metabotropically, without the need for Ca2+. This review highlights novel findings concerning these unconventional modes of NMDAR action.

Original languageEnglish (US)
Pages (from-to)10800-10807
Number of pages8
JournalJournal of Neuroscience
Issue number45
StatePublished - Nov 8 2017


  • Alzheimer’s disease
  • LTD
  • LTP
  • Metabotropic NMDA receptor
  • Presynaptic NMDA receptor
  • Short-term plasticity

ASJC Scopus subject areas

  • Medicine(all)


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