Uncertainties and challenges in surgical and transcatheter tricuspid valve therapy: A state-of-the-art expert review

Chun Chin Chang, Kevin M. Veen, Rebecca T. Hahn, Ad J.J.C. Bogers, Azeem Latib, Frans B.S. Oei, Mohammad Abdelghani, Rodrigo Modolo, Siew Yen Ho, Mohamed Abdel-Wahab, Khalil Fattouch, Johan Bosmans, Kadir Caliskan, Maurizio Taramasso, Patrick W. Serruys, Jeroen J. Bax, Nicolas M.D.A. Van Mieghem, Johanna J.M. Takkenberg, Philip Lurz, Thomas ModineOsama Soliman

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Tricuspid regurgitation (TR) is a frequent and complex problem, commonly combined with left-sided heart disease, such as mitral regurgitation. Significant TR is associated with increased mortality if left untreated or recurrent after therapy. Tricuspid regurgitation was historically often disregarded and remained undertreated. Surgery is currently the only Class I Guideline recommended therapy for TR, in the form of annuloplasty, leaflet repair, or valve replacement. As growing experience of transcatheter therapy in structural heart disease, many dedicated transcatheter tricuspid repair or replacement devices, which mimic well-established surgical techniques, are currently under development. Nevertheless, many aspects of TR are little understood, including the disease process, surgical or interventional risk stratification, and predictors of successful therapy. The optimal treatment timing and the choice of proper surgical or interventional technique for significant TR remain to be elucidated. In this context, we aim to highlight the current evidence, underline major controversial issues in this field and present a future roadmap for TR therapy.

Original languageEnglish (US)
Pages (from-to)1932-1940
Number of pages9
JournalEuropean heart journal
Issue number20
StatePublished - May 21 2020


  • Heart failure
  • Imaging
  • Outcome
  • Risk
  • Treatment
  • Tricuspid regurgitation
  • Tricuspid valve

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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