Ultrastructure of neurites and meganeurites of cortical pyramidal neurons in feline gangliosidosis as revealed by the combined Golgi-EM technique

S. U. Walkley; S. Wurzelmann; D. P. Purpura

doi:10.1016/0006-8993(81)90711-3

Ultrastructure of neurites and meganeurites of cortical pyramidal neurons in feline gangliosidosis as revealed by the combined Golgi-EM technique

S. U. Walkley, S. Wurzelmann, D. P. Purpura

Neuroscience

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Application of the Golgi-EM technique to the studt of altered cortical pyramidal neuron morphology in feline gangliosidosis has revealed the presence of aberrant synapses in relation to multiple neurites and secondary neurites of meganeurites. In addition fine neurites arising from the soma and meganeurite are found to project into and envelope elements of the sorrounding neuropil. These observations provide further evidence for a disturbance in neuronal surface membrane regulation in ganglioside storage disease.

Original language	English (US)
Pages (from-to)	393-398
Number of pages	6
Journal	Brain research
Volume	211
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(81)90711-3
State	Published - May 4 1981

Keywords

aberrant neurite
animal model
combined Golgi-EM technique
gangliosidosis
pyramidal neuron

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(81)90711-3

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title = "Ultrastructure of neurites and meganeurites of cortical pyramidal neurons in feline gangliosidosis as revealed by the combined Golgi-EM technique",

abstract = "Application of the Golgi-EM technique to the studt of altered cortical pyramidal neuron morphology in feline gangliosidosis has revealed the presence of aberrant synapses in relation to multiple neurites and secondary neurites of meganeurites. In addition fine neurites arising from the soma and meganeurite are found to project into and envelope elements of the sorrounding neuropil. These observations provide further evidence for a disturbance in neuronal surface membrane regulation in ganglioside storage disease.",

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AU - Walkley, S. U.

AU - Wurzelmann, S.

AU - Purpura, D. P.

PY - 1981/5/4

Y1 - 1981/5/4

N2 - Application of the Golgi-EM technique to the studt of altered cortical pyramidal neuron morphology in feline gangliosidosis has revealed the presence of aberrant synapses in relation to multiple neurites and secondary neurites of meganeurites. In addition fine neurites arising from the soma and meganeurite are found to project into and envelope elements of the sorrounding neuropil. These observations provide further evidence for a disturbance in neuronal surface membrane regulation in ganglioside storage disease.

AB - Application of the Golgi-EM technique to the studt of altered cortical pyramidal neuron morphology in feline gangliosidosis has revealed the presence of aberrant synapses in relation to multiple neurites and secondary neurites of meganeurites. In addition fine neurites arising from the soma and meganeurite are found to project into and envelope elements of the sorrounding neuropil. These observations provide further evidence for a disturbance in neuronal surface membrane regulation in ganglioside storage disease.

KW - aberrant neurite

KW - animal model

KW - combined Golgi-EM technique

KW - gangliosidosis

KW - pyramidal neuron

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ER -

Ultrastructure of neurites and meganeurites of cortical pyramidal neurons in feline gangliosidosis as revealed by the combined Golgi-EM technique

Abstract

Keywords

ASJC Scopus subject areas

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