Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt‐Jakob disease

Toshihiko Suenaga; Asao Hirano; Josefina F. Llena; Hanna Ksiezak‐Reding; Shu‐Hui ‐H Yen; Dennis W. Dickson

doi:10.1002/ana.410280210

Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt‐Jakob disease

Toshihiko Suenaga, Asao Hirano, Josefina F. Llena, Hanna Ksiezak‐Reding, Shu‐Hui ‐H Yen, Dennis W. Dickson

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Cerebellar kuru plaques in 2 cases of Creutzfeldt‐Jakob disease were studied immunohistochemically. Similar to cerebellar senile plaques in Alzheimer's disease, many kuru plaques contained ubiquitin‐positive, tau‐negative small granular elements, presumably representing dystrophic neurites. Our results suggest that similar mechanisms are involved in neuritic changes in cerebellar plaques in Creutzfeldt‐Jakob and Alzheimer's diseases despite differences of amyloid proteins in the plaques.

Original language	English (US)
Pages (from-to)	174-177
Number of pages	4
Journal	Annals of Neurology
Volume	28
Issue number	2
DOIs	https://doi.org/10.1002/ana.410280210
State	Published - Aug 1990
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1002/ana.410280210

Cite this

@article{d52360cc665e4190bf5c199bc407d115,

title = "Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt‐Jakob disease",

abstract = "Cerebellar kuru plaques in 2 cases of Creutzfeldt‐Jakob disease were studied immunohistochemically. Similar to cerebellar senile plaques in Alzheimer's disease, many kuru plaques contained ubiquitin‐positive, tau‐negative small granular elements, presumably representing dystrophic neurites. Our results suggest that similar mechanisms are involved in neuritic changes in cerebellar plaques in Creutzfeldt‐Jakob and Alzheimer's diseases despite differences of amyloid proteins in the plaques.",

author = "Toshihiko Suenaga and Asao Hirano and Llena, {Josefina F.} and Hanna Ksiezak‐Reding and Yen, {Shu‐Hui ‐H} and Dickson, {Dennis W.}",

year = "1990",

month = aug,

doi = "10.1002/ana.410280210",

language = "English (US)",

volume = "28",

pages = "174--177",

journal = "Annals of Neurology",

issn = "0364-5134",

publisher = "John Wiley and Sons Inc.",

number = "2",

}

TY - JOUR

T1 - Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt‐Jakob disease

AU - Suenaga, Toshihiko

AU - Hirano, Asao

AU - Llena, Josefina F.

AU - Ksiezak‐Reding, Hanna

AU - Yen, Shu‐Hui ‐H

AU - Dickson, Dennis W.

PY - 1990/8

Y1 - 1990/8

N2 - Cerebellar kuru plaques in 2 cases of Creutzfeldt‐Jakob disease were studied immunohistochemically. Similar to cerebellar senile plaques in Alzheimer's disease, many kuru plaques contained ubiquitin‐positive, tau‐negative small granular elements, presumably representing dystrophic neurites. Our results suggest that similar mechanisms are involved in neuritic changes in cerebellar plaques in Creutzfeldt‐Jakob and Alzheimer's diseases despite differences of amyloid proteins in the plaques.

AB - Cerebellar kuru plaques in 2 cases of Creutzfeldt‐Jakob disease were studied immunohistochemically. Similar to cerebellar senile plaques in Alzheimer's disease, many kuru plaques contained ubiquitin‐positive, tau‐negative small granular elements, presumably representing dystrophic neurites. Our results suggest that similar mechanisms are involved in neuritic changes in cerebellar plaques in Creutzfeldt‐Jakob and Alzheimer's diseases despite differences of amyloid proteins in the plaques.

UR - http://www.scopus.com/inward/record.url?scp=0025124781&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025124781&partnerID=8YFLogxK

U2 - 10.1002/ana.410280210

DO - 10.1002/ana.410280210

M3 - Article

C2 - 2171419

AN - SCOPUS:0025124781

SN - 0364-5134

VL - 28

SP - 174

EP - 177

JO - Annals of Neurology

JF - Annals of Neurology

IS - 2

ER -

Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt‐Jakob disease

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this