Two types of receptors for iron on mitochondria

J. Weaver; S. Pollack

doi:10.1042/bj2710463

Two types of receptors for iron on mitochondria

J. Weaver, S. Pollack

Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

ATP, the major ligand for Fe in the reticulocyte's low-M(r) chelatable pool, transfers Fe to a mitochondrial receptor from which the Fe is incorporated into haem. However, the utilization of Fe bound to this receptor for haem synthesis is slow in comparison with that bound to a second receptor that does not accept Fe from ATP, but does accept it from AMP. The major pathway by which Fe is delivered for haem synthesis may be through hydrolysis of cytosolic ATP-Fe to AMP-Fe.

Original language	English (US)
Pages (from-to)	463-466
Number of pages	4
Journal	Biochemical Journal
Volume	271
Issue number	2
DOIs	https://doi.org/10.1042/bj2710463
State	Published - 1990

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Two types of receptors for iron on mitochondria",

abstract = "ATP, the major ligand for Fe in the reticulocyte's low-M(r) chelatable pool, transfers Fe to a mitochondrial receptor from which the Fe is incorporated into haem. However, the utilization of Fe bound to this receptor for haem synthesis is slow in comparison with that bound to a second receptor that does not accept Fe from ATP, but does accept it from AMP. The major pathway by which Fe is delivered for haem synthesis may be through hydrolysis of cytosolic ATP-Fe to AMP-Fe.",

author = "J. Weaver and S. Pollack",

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AB - ATP, the major ligand for Fe in the reticulocyte's low-M(r) chelatable pool, transfers Fe to a mitochondrial receptor from which the Fe is incorporated into haem. However, the utilization of Fe bound to this receptor for haem synthesis is slow in comparison with that bound to a second receptor that does not accept Fe from ATP, but does accept it from AMP. The major pathway by which Fe is delivered for haem synthesis may be through hydrolysis of cytosolic ATP-Fe to AMP-Fe.

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Two types of receptors for iron on mitochondria

Abstract

ASJC Scopus subject areas

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