Twists and turns of invasion

Geoffrey Childs, Jeffrey E. Segall

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The transcription factor Twist1 is overexpressed in tumours and can induce the epithelial-mesenchymal transition, resulting in increased invasiveness. Twist1 is now shown to regulate cancer cell migration and invasion in three-dimensional environments by activating the RAC1 GTPase through suppression of a let-7 microRNA family member.

Original languageEnglish (US)
Pages (from-to)337-339
Number of pages3
JournalNature Cell Biology
Issue number4
StatePublished - Apr 2012

ASJC Scopus subject areas

  • Cell Biology


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