Twists and turns of invasion

Geoffrey Childs; Jeffrey E. Segall

doi:10.1038/ncb2477

Twists and turns of invasion

Geoffrey Childs, Jeffrey E. Segall

Pathology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The transcription factor Twist1 is overexpressed in tumours and can induce the epithelial-mesenchymal transition, resulting in increased invasiveness. Twist1 is now shown to regulate cancer cell migration and invasion in three-dimensional environments by activating the RAC1 GTPase through suppression of a let-7 microRNA family member.

Original language	English (US)
Pages (from-to)	337-339
Number of pages	3
Journal	Nature Cell Biology
Volume	14
Issue number	4
DOIs	https://doi.org/10.1038/ncb2477
State	Published - Apr 2012

ASJC Scopus subject areas

Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ncb2477

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abstract = "The transcription factor Twist1 is overexpressed in tumours and can induce the epithelial-mesenchymal transition, resulting in increased invasiveness. Twist1 is now shown to regulate cancer cell migration and invasion in three-dimensional environments by activating the RAC1 GTPase through suppression of a let-7 microRNA family member.",

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AB - The transcription factor Twist1 is overexpressed in tumours and can induce the epithelial-mesenchymal transition, resulting in increased invasiveness. Twist1 is now shown to regulate cancer cell migration and invasion in three-dimensional environments by activating the RAC1 GTPase through suppression of a let-7 microRNA family member.

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Twists and turns of invasion

Abstract

ASJC Scopus subject areas

UN SDGs

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