Tunicamycin‐mediated depletion of insulin receptors in 3T3‐L1 adipocytes

O. M. Rosen, G. H. Chia, C. Fung, C. S. Rubin

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Tunicamycin, an antibiotic that inhibits protein glycosylation, elicited a rapid depletion of insulin binding activity at the surface of 3T3‐L1 adipocytes. Disappearance of insulin receptors occurred more rapidly in the presence of tunicamycin than when protein synthesis was inhibited by cycloheximide and was accompanied by a diminution in sensitivity of the adipocytes to the acute effects of insulin and anit‐insulin receptor antibody on hexose uptake and metabolism.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalJournal of Cellular Physiology
Issue number1
StatePublished - Apr 1979

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology


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