Tryptophan depletion in SSRI-recovered depressed outpatients

M. K. Spillmann, A. J.W. Van der Does, M. A. Rankin, R. D. Vuolo, J. E. Alpert, A. A. Nierenberg, J. F. Rosenbaum, D. Hayden, D. Schoenfeld, M. Fava

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Rationale: Recently, a number of studies have challenged the finding that acute tryptophan depletion (TD) increases depressive symptoms in medicated, formerly depressed patients. The present study examined the effects of acute nutritional TD on remitted depressed patients currently treated with selective serotonin reup-take inhibitors. In an attempt to clarify conflicting earlier findings, the effects of a number of clinical variables on outcome were also investigated. Methods: Ten patients underwent TD in a double-blind, controlled, balanced crossover fashion. The control session followed the procedure of Krahn et al. (1996 Neuropsychopharmacology 15:325-328). Sessions were 5-8 days apart. Results: TD was significantly related to increased scores on clinician-rated depression and anxiety scales, and on self-rated depression, anxiety, and somatic symptoms. The control challenge had no effect, despite the fact that the reductions in plasma tryptophan during the control session were unexpectedly high. Some evidence was found for a threshold in the relationship between reduction of plasma tryptophan and mood response. Conclusions: The mood effect of TD in medicated, formerly depressed patients was confirmed. A threshold may exist for mood effects following TD, implying that recent negative findings may have been caused by insufficient depletion. No other predicting or mediating factors were identified, although the variable "history of response pattern to medication" deserves further study.

Original languageEnglish (US)
Pages (from-to)123-127
Number of pages5
Issue number2
StatePublished - 2001
Externally publishedYes


  • Depression Antidepressant
  • Mood effect
  • Remission
  • Tryptophan depletion

ASJC Scopus subject areas

  • Pharmacology


Dive into the research topics of 'Tryptophan depletion in SSRI-recovered depressed outpatients'. Together they form a unique fingerprint.

Cite this