Trypanosoma cruzi infection: A review with emphasis on cutaneous manifestations

Vagish Hemmige, Herbert Tanowitz, Aisha Sethi

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


Chagas disease, an infection caused by the protozoan Trypanosoma cruzi and transmitted by the Reduuvid insect vector, remains a major cause of morbidity in Central and South America over a century after its discovery in 1909. Though major advances in preventing the spread of this disease have been made in recent decades, millions of individuals remain chronically infected due to prior exposure to T. cruzi and are at risk for future complications from the disease. Dermatologic manifestations of acute infection may include localized swelling at the site of inoculation (chagoma), conjunctivitis (Romaña's sign), and a generalized morbilliform eruption (schizotrypanides). Reactivation of quiescent infection in immunocompromised hosts due to the acquired immunodeficiency syndrome or organ transplantation can present with fever and skin lesions including panniculitis. The widespread emigration of chronic carriers of T. cruzi to North America, Europe, and Australia makes it imperative that dermatologists worldwide be familiar with this entity to ensure proper diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)501-508
Number of pages8
JournalInternational Journal of Dermatology
Issue number5
StatePublished - May 2012
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


Dive into the research topics of 'Trypanosoma cruzi infection: A review with emphasis on cutaneous manifestations'. Together they form a unique fingerprint.

Cite this