Trypanosoma cruzi and Chagas Disease: Innate Immunity, ROS, and Cardiovascular System

Herbert B. Tanowitz; Jian jun Wen; Fabiana S. Machado; Mahalia S. Desruisseaux; Carlos Robello; Nisha J. Garg

doi:10.1016/B978-0-12-801078-5.00014-5

Trypanosoma cruzi and Chagas Disease: Innate Immunity, ROS, and Cardiovascular System

Herbert B. Tanowitz, Jian jun Wen, Fabiana S. Machado, Mahalia S. Desruisseaux, Carlos Robello, Nisha J. Garg

Research output: Chapter in Book/Report/Conference proceeding › Chapter

11 Scopus citations

Abstract

Chagas disease, caused by Trypanosoma cruzi, remains an important neglected disease and a cause of significant morbidity and mortality. No longer confined to endemic areas of Latin America, it is now found in nonendemic areas due to immigration and/or natural transmission. The pathogenesis of Chagas disease is complex and multifactorial. The significance of innate immunity, including the contributions of cytokines, chemokines, and reactive oxygen species, has been emphasized. The components of the eicosanoid pathway, such as thromboxane A₂ and the lipoxins, have profound effects as pro- and anti-inflammatory factors. Additionally, we discuss the vasoconstrictive actions of thromboxane A₂ and endothelin-1 in Chagas disease.

Original language	English (US)
Title of host publication	Vascular Responses to Pathogens
Publisher	Elsevier Inc.
Pages	183-193
Number of pages	11
ISBN (Electronic)	9780128013250
ISBN (Print)	9780128010785
DOIs	https://doi.org/10.1016/B978-0-12-801078-5.00014-5
State	Published - 2016

Keywords

Chagas disease
Endothelin
Reactive oxygen species
Thromboxane A
Trypanosoma cruzi
Vasoconstriction

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-801078-5.00014-5

Cite this

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title = "Trypanosoma cruzi and Chagas Disease: Innate Immunity, ROS, and Cardiovascular System",

abstract = "Chagas disease, caused by Trypanosoma cruzi, remains an important neglected disease and a cause of significant morbidity and mortality. No longer confined to endemic areas of Latin America, it is now found in nonendemic areas due to immigration and/or natural transmission. The pathogenesis of Chagas disease is complex and multifactorial. The significance of innate immunity, including the contributions of cytokines, chemokines, and reactive oxygen species, has been emphasized. The components of the eicosanoid pathway, such as thromboxane A2 and the lipoxins, have profound effects as pro- and anti-inflammatory factors. Additionally, we discuss the vasoconstrictive actions of thromboxane A2 and endothelin-1 in Chagas disease.",

keywords = "Chagas disease, Endothelin, Reactive oxygen species, Thromboxane A, Trypanosoma cruzi, Vasoconstriction",

author = "Tanowitz, {Herbert B.} and Wen, {Jian jun} and Machado, {Fabiana S.} and Desruisseaux, {Mahalia S.} and Carlos Robello and Garg, {Nisha J.}",

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T2 - Innate Immunity, ROS, and Cardiovascular System

AU - Tanowitz, Herbert B.

AU - Wen, Jian jun

AU - Machado, Fabiana S.

AU - Desruisseaux, Mahalia S.

AU - Robello, Carlos

AU - Garg, Nisha J.

PY - 2016

Y1 - 2016

N2 - Chagas disease, caused by Trypanosoma cruzi, remains an important neglected disease and a cause of significant morbidity and mortality. No longer confined to endemic areas of Latin America, it is now found in nonendemic areas due to immigration and/or natural transmission. The pathogenesis of Chagas disease is complex and multifactorial. The significance of innate immunity, including the contributions of cytokines, chemokines, and reactive oxygen species, has been emphasized. The components of the eicosanoid pathway, such as thromboxane A2 and the lipoxins, have profound effects as pro- and anti-inflammatory factors. Additionally, we discuss the vasoconstrictive actions of thromboxane A2 and endothelin-1 in Chagas disease.

AB - Chagas disease, caused by Trypanosoma cruzi, remains an important neglected disease and a cause of significant morbidity and mortality. No longer confined to endemic areas of Latin America, it is now found in nonendemic areas due to immigration and/or natural transmission. The pathogenesis of Chagas disease is complex and multifactorial. The significance of innate immunity, including the contributions of cytokines, chemokines, and reactive oxygen species, has been emphasized. The components of the eicosanoid pathway, such as thromboxane A2 and the lipoxins, have profound effects as pro- and anti-inflammatory factors. Additionally, we discuss the vasoconstrictive actions of thromboxane A2 and endothelin-1 in Chagas disease.

KW - Chagas disease

KW - Endothelin

KW - Reactive oxygen species

KW - Thromboxane A

KW - Trypanosoma cruzi

KW - Vasoconstriction

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M3 - Chapter

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SN - 9780128010785

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BT - Vascular Responses to Pathogens

PB - Elsevier Inc.

ER -

Trypanosoma cruzi and Chagas Disease: Innate Immunity, ROS, and Cardiovascular System

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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