Abstract
In recent years a new mechanism of genetic disease has been discovered in which triplet DNA sequences (trinucleotides) expand either to interrupt or to compromise a gene. So far, ten genetic loci have been identified in which this event takes place. The presence of these expansions, sometimes containing thousands of repeated trinucleotides, provides a clue as to how processing of DNA and RNA may sometimes go awry. How this expansion in a single allele may exert a dominant effect and how the extent of the expansion increases the severity of the disease remain a mystery.
Original language | English (US) |
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Pages (from-to) | 65-69 |
Number of pages | 5 |
Journal | Molecular Medicine Today |
Volume | 2 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1996 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine
- Genetics