Triple-negative breast carcinoma: Current and emerging concepts

Robert Schmadeka, Bryan E. Harmon, Meenakshi Singh

Research output: Contribution to journalReview articlepeer-review

138 Scopus citations


Objectives: Triple-negative breast cancer is regarded as an aggressive disease that affects a young patient population and for which effective targeted therapy is not yet available. Methods: Intense efforts have been made to gain a better understanding of this heterogeneous group of tumors from the histologic to the genomic and molecular levels. Results: Progress has been made, including the ability to subtype these tumors and the discovery of biomarkers toward which current therapeutic efforts are focused. Many novel targets under exploration have the potential to affect the clinical course of this disease. Conclusions This article reviews the current concepts regarding the clinicopathologic features of triple-negative breast carcinoma, its histologic subtypes, molecular classification, the prognostic and therapeutic potential of biomarkers, and emerging targeted therapies.

Original languageEnglish (US)
Pages (from-to)462-477
Number of pages16
JournalAmerican journal of clinical pathology
Issue number4
StatePublished - Apr 2014
Externally publishedYes


  • Biomarkers
  • Breast cancer
  • Pathology
  • Therapeutic efforts
  • Triple negative

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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